Hospital-onset sepsis is associated with a higher in-hospital mortality rate than community-onset sepsis. Many hospitals have implemented rapid response teams (RRTs) for early detection and timely management of at-risk hospitalized patients. However, the effectiveness of an all-day RRT over a non-all-day RRT in reducing the risk of in-hospital mortality in patient with hospital-onset sepsis is unclear. We aimed to determine the effect of the RRT’s operating hours on in-hospital mortality in inpatient patients with sepsis. We conducted a nationwide cohort study of adult patients with hospital-onset sepsis prospectively collected from the Korean Sepsis Alliance (KSA) Database from 16 tertiary referral or university-affiliated hospitals in South Korea between September of 2019 and February of 2020. RRT was implemented in 11 hospitals, of which 5 (45.5%) operated 24-h RRT (all-day RRT) and the remaining 6 (54.5%) had part-day RRT (non-all-day RRT). The primary outcome was in-hospital mortality between the two groups. Of the 405 patients with hospital-onset sepsis, 206 (50.9%) were admitted to hospitals operating all-day RRT, whereas 199 (49.1%) were hospitalized in hospitals with non-all-day RRT. A total of 73 of the 206 patients in the all-day group (35.4%) and 85 of the 199 patients in the non-all-day group (42.7%) died in the hospital (P = 0.133). After adjustments for co-variables, the implementation of all-day RRT was associated with a significant reduction in in-hospital mortality (adjusted odds ratio 0.57; 95% confidence interval 0.35–0.93; P = 0.024). In comparison with non-all-day RRTs, the availability of all-day RRTs was associated with reduced in-hospital mortality among patients with hospital-onset sepsis.

中文翻译：

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医院内全天和非全天快速反应小组医院发病脓毒症患者的死亡率：一项前瞻性全国多中心队列研究

与社区发病的脓毒症相比，医院发病的脓毒症与更高的住院死亡率相关。许多医院已经实施了快速反应小组 (RRT)，以便及早发现和及时管理有风险的住院患者。然而，全天 RRT 与非全天 RRT 在降低住院脓毒症患者院内死亡风险方面的有效性尚不清楚。我们旨在确定 RRT 的运行时间对脓毒症住院患者住院死亡率的影响。我们对 2019 年 9 月至 2020 年 2 月期间从韩国 16 家三级转诊医院或大学附属医院的韩国脓毒症联盟 (KSA) 数据库前瞻性收集的住院脓毒症成人患者进行了一项全国性队列研究。RRT 在11家医院，其中5家（45. 5%) 进行了 24 小时 RRT（全天 RRT），其余 6 人（54.5%）进行了部分天 RRT（非全天 RRT）。主要结果是两组之间的住院死亡率。在 405 名院内发病的脓毒症患者中，206 人（50.9%）入院进行全天 RRT 的医院，而 199 人（49.1%）在非全天 RRT 的医院住院。全天组206例患者中有73例（35.4%）和非全天组199例患者中有85例（42.7%）在医院死亡（P=0.133）。在对协变量进行调整后，全天 RRT 的实施与住院死亡率显着降低相关（调整后的优势比 0.57；95% 置信区间 0.35-0.93；P = 0.024）。与非全天 RRT 相比，