Smoking, alcohol and coffee consumption and risk of low back pain: a Mendelian randomization study,European Spine Journal

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Smoking, alcohol and coffee consumption and risk of low back pain: a Mendelian randomization study
European Spine Journal ( IF 2.6 ) Pub Date : 2022-09-16 , DOI: 10.1007/s00586-022-07389-3
Zhengtao Lv ₁ , Jiarui Cui ₂ , Jiaming Zhang ₁

Affiliation

Purpose

Low back pain (LBP) is a common health problem in the global population. This study aims to assess whether smoking initiation, alcohol consumption, and coffee consumption are causally with an increased risk of LBP.

Methods

A two-sample Mendelian Randomization (MR) study was designed, based on summary-level data from the largest published genome-wide association studies. Single nucleotide polymorphisms with genome-wide significance level (P < 5.0 × 10⁻⁸) were selected as instrumental variables for each exposure. Standard inverse-variance weighted (IVW) method was used as the primary statistical method. The weighted median, MR-Egger regression, and MR-PRESSO methods, which relax some IV assumptions, were used for sensitivity analysis.

Results

Genetically predicted smoking initiation was causally associated with higher odds of LBP. The pooled OR of LBP using IVW method was 1.36 (95%CI 1.22 1.52; P = 6.0 × 10⁻⁸) for one SD increase in the prevalence of smoking initiation, which was supported by the weighted median method (OR: 1.41, 95%CI 1.22, 1.64; P = 5.7 × 10⁻⁶). Sensitivity analysis confirmed the robustness of pooled OR of LBP. There was no evidence to suggest a causal effect of alcohol and coffee consumption on LBP. The pooled ORs of LBP were 1.36 (95%CI 0.94, 1.97; P = 0.10) for alcohol consumption and 1.00 (95%CI 0.99, 1.00; P = 0.17) for coffee consumption, respectively.

Conclusion

Smoking is casually associated with an increased risk of LBP. Smoking control should be recommended in LBP patients to avoid worsening the disease. The safety of LBP with moderate alcohol and coffee consumption merits more study.

中文翻译：

吸烟、饮酒和喝咖啡与腰痛的风险：一项孟德尔随机研究

目的

腰痛 (LBP) 是全球人口中常见的健康问题。本研究旨在评估开始吸烟、饮酒和喝咖啡是否与 LBP 风险增加有因果关系。

方法

基于已发表的最大的全基因组关联研究的汇总数据，设计了一项双样本孟德尔随机化 (MR) 研究。选择具有全基因组显着性水平 ( P < 5.0 × 10 ^-8 ) 的单核苷酸多态性作为每次暴露的工具变量。标准逆方差加权（IVW）方法被用作主要统计方法。加权中位数、MR-Egger 回归和 MR-PRESSO 方法放宽了一些 IV 假设，用于敏感性分析。

结果

遗传预测的吸烟开始与 LBP 的较高几率有因果关系。使用 IVW 方法的 LBP 合并 OR 为 1.36 (95%CI 1.22 1.52; P = 6.0 × 10 ^-8 ) 对于开始吸烟的流行率增加一个 SD，这得到加权中位数方法的支持 (OR: 1.41, 95 %CI 1.22, 1.64；P = 5.7 × 10 ^-6 )。敏感性分析证实了 LBP 合并 OR 的稳健性。没有证据表明饮酒和喝咖啡对 LBP 有因果影响。LBP 的合并 OR 分别为饮酒 1.36（95%CI 0.94，1.97；P = 0.10）和咖啡消费 1.00（95%CI 0.99，1.00；P = 0.17）。