Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives,ChemMedChem

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Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives
ChemMedChem ( IF 3.6 ) Pub Date : 2022-09-15 , DOI: 10.1002/cmdc.202200476
Maria João Matos _{1,

2} , Eugenio Uriarte _{1,

3} , Nuria Seoane ₄ , Aitor Picos ₄ , José Gil-Longo ₄ , Manuel Campos-Toimil ₄

Affiliation

Relaxation time: Synthesized nitrate−coumarins show potent vasodilator activity on isolated rat aortic rings deprived of endothelium, with a higher effect on those rings pre-contracted with phenylephrine than potassium chloride. This suggests that the opening of potassium channels may be involved in their vasorelaxant mechanism of action.

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