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The antitumor properties of atractylenolides: Molecular mechanisms and signaling pathways
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2022-09-16 , DOI: 10.1016/j.biopha.2022.113699
Yu Jiang 1 , Kaibo Guo 2 , Peipei Wang 1 , Ying Zhu 1 , Jiaqi Huang 3 , Shanming Ruan 4
Affiliation  

Drugs that exhibit a high degree of tumor cell selectivity while minimizing normal cell toxicity are an area of active research interest as a means of designing novel antitumor agents. The pharmacological benefits of Chinese herbal medicine-based treatments have been the focus of growing research interest in recent years. Sesquiterpenoids derived from the Atractylodes macrocephala volatile oil preparations exhibit in vitro and in vivo antitumor activity. Atracylenolides exhibit anti-proliferative, anti-metastatic, and immunomodulatory activity in a range of tumor cell lines in addition to being capable of regulating metabolic activity such that it is a promising candidate drug for the treatment of diverse cancers. The present review provides a summary of recent advances in Atractylenolide-focused antitumor research efforts.



中文翻译:

白术内酯的抗肿瘤特性:分子机制和信号通路

表现出高度的肿瘤细胞选择性同时最大限度地减少正常细胞毒性的药物作为设计新型抗肿瘤剂的手段是一个活跃的研究领域。近年来,以中草药为基础的治疗方法的药理益处一直是研究关注的焦点。白术衍生的倍半萜类化合物挥发油制剂表现出体外和体内抗肿瘤活性。Aracylenolides 在一系列肿瘤细胞系中表现出抗增殖、抗转移和免疫调节活性,此外还能够调节代谢活性,使其成为治疗多种癌症的有希望的候选药物。本综述总结了以白术内酯为重点的抗肿瘤研究工作的最新进展。

更新日期:2022-09-16
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