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Antimicrobial Functionalization of Prolamine–Silica Hybrid Coatings with Fumaric Acid for Food Packaging Materials and Their Biocompatibility
Antibiotics ( IF 4.3 ) Pub Date : 2022-09-16 , DOI: 10.3390/antibiotics11091259
Franziska Trodtfeld 1, 2 , Tina Tölke 2 , Cornelia Wiegand 1
Affiliation  

The interest of the food packaging industry in biodegradable, recyclable, and functional materials has steadily increased in recent years. The use of hydrogels in the food sector holds great potential for use in packaging systems or as carriers for bioactive substances. The synthesis of an oxygen barrier coating of prolaminic silica material and antimicrobial functionalization with fumaric acid for packaging materials described here is an elegant way to meet these requirements. The developed material achieved a significant antimicrobial activity against Escherichia coli and Staphylococcus aureus, two common clinical pathogens. Another pre-requisite of such materials is a high biocompatibility, which can be assessed using human cell models, to help ensure consumer safety. The biocompatibility was determined by luminescence adenosine triphosphate and photometric lactate dehydrogenase assays. No cytotoxic effects on human keratinocytes in vitro were found for the test materials.

中文翻译:

用于食品包装材料的富马酸醇溶谷蛋白-二氧化硅杂化涂层的抗菌功能化及其生物相容性

近年来,食品包装行业对可生物降解、可回收和功能材料的兴趣稳步增加。水凝胶在食品领域的使用在包装系统或作为生物活性物质的载体方面具有巨大的潜力。此处描述的用于包装材料的醇溶性二氧化硅材料的氧阻隔涂层的合成和富马酸的抗菌功能化是满足这些要求的一种优雅方法。开发的材料对大肠杆菌金黄色葡萄球菌具有显着的抗菌活性,两种常见的临床病原体。这种材料的另一个先决条件是高生物相容性,可以使用人体细胞模型进行评估,以帮助确保消费者的安全。通过发光三磷酸腺苷和光度乳酸脱氢酶测定法确定生物相容性。对于测试材料,未发现体外对人角质形成细胞的细胞毒性作用。
更新日期:2022-09-16
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