Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease,Alzheimer's & Dementia

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Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-09-15 , DOI: 10.1002/alz.12759
Herman Depypere ₁ , Andrea Vergallo ₂ , Pablo Lemercier ₂ , Simone Lista ₂ , Andrea Benedet ₃ , Nicholas Ashton _{3,

4,

5,

6} , Enrica Cavedo ₂ , Henrik Zetterberg _{3,

7,

8,

9,

10} , Kaj Blennow _{3,

7} , Eugeen Vanmechelen ₁₁ , Harald Hampel ₂ ,

Affiliation

Department of Gynecology, Breast and Menopause Clinic, University Hospital, Coupure Menopause Centre, Ghent, Belgium.
Sorbonne University, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, Paris, France.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
ADx NeuroSciences, Ghent, Belgium.

This increasing body of literature indicates that menopause hormonal replacement therapy (MHT) may substantially mitigate the risk of developing late-life cognitive decline due to progressive Alzheimer's disease (AD) pathophysiology. For the first time, we investigated the question whether MHT impacts AD biomarker-informed pathophysiological dynamics in de-novo diagnosed menopausal women.

中文翻译：

更年期激素治疗显着改变阿尔茨海默病的病理生理生物标志物

越来越多的文献表明，更年期激素替代疗法 (MHT) 可能会大大降低由于进行性阿尔茨海默病 (AD) 病理生理学而导致晚年认知能力下降的风险。我们首次调查了 MHT 是否影响新诊断的绝经期妇女的 AD 生物标志物知情病理生理动力学的问题。

更新日期：2022-09-15

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