Introduction: While prior studies have generally reported rigorous protocols using prespecified CT scanner settings for HU measurements, the present study sought to report on the correlation between DXA and HUs recorded using several CT scanners with varying sequences, simulating measurements performed in “real-world” hospital and Emergency Department (ED) settings. Methodology: Six raters performed HU measurements of trabecular bone at the L1 vertebral body for forty consecutive patients on Phillips and General Electric (GE) abdominal CT scans obtained between 2017 and 2021. Inter-rater reliability of the HU measurements and their correlations with recorded DXA-based bone assessments were determined. Correlation coefficients were calculated for the HU measurements between scanner vendors as well as for the CT HUs with each DXA measurement. Results: The ICC for L1 HUs read on the Phillips and GE scanners were 0.85 and 0.82, respectively, indicating excellent agreement. The correlation coefficient for the mean HUs on the Phillips and GE scanners was 0.92, also indicating excellent correlation. For both scanner vendors, the HU values most closely correlated with the total femur and femoral neck T-scores. Conclusions: HU values recorded on a Phillips and GE scanner both demonstrated excellent inter-rater reliability. Correlations were strongest between L1 HU values and total femur DXA T-scores. Readily available abdominal CT image data across multiple hospital settings can be utilized by providers of varying level of imaging interpretation expertise to determine vertebral body Hounsfield units that may help identify osteoporosis risk without additional radiation exposure or cost.

简介：虽然之前的研究通常报告了使用预先指定的 CT 扫描仪设置进行 HU 测量的严格协议，但本研究试图报告使用具有不同序列的多个 CT 扫描仪记录的 DXA 和 HU 之间的相关性，模拟在“真实世界”中执行的测量医院和急诊科 (ED) 设置。方法：六名评估者对 L1椎体的小梁骨进行了 HU 测量对 2017 年至 2021 年间获得的连续 40 名接受菲利普斯和通用电气 (GE) 腹部 CT 扫描的患者进行了检查。确定了 HU 测量值的评估者间可靠性及其与记录的基于 DXA 的骨骼评估的相关性。为扫描仪供应商之间的 HU 测量以及每次 DXA 测量的 CT HU 计算相关系数。结果：在 Phillips 和 GE 扫描仪上读取的 L1 HU 的 ICC 分别为 0.85 和 0.82，表明非常一致。Phillips 和 GE 扫描仪上平均 HU 的相关系数为 0.92，也表明相关性极好。对于两家扫描仪供应商而言，HU 值与总股骨和股骨颈 T 值的相关性最为密切。结论：在 Phillips 和 GE 扫描仪上记录的 HU 值均表现出出色的评分者间可靠性。L1 HU 值与总股骨 DXA T 分数之间的相关性最强。不同水平的成像解释专业知识的提供者可以利用多个医院环境中现成的腹部 CT 图像数据来确定椎体 Hounsfield 单位，这可能有助于识别骨质疏松症风险，而无需额外的辐射暴露或成本。