Herbal drugs offer an alternative approach for the treatment of diseases like asthma due to low cost and comparatively less adverse effects in contrast to synthetic drugs. Leaves of Quercus leucotrichophora are traditionally used for the treatment of asthma. The study was aimed to assess the anti-asthmatic activity of Quercus leucotrichophora (QL) methanolic (QLME) and aqueous extracts (QLAE) in ovalbumin-(OVA) induced asthma and chemical characterization of QL extract by High Performance Liquid Chromatography-Diode array detector (HPLC-DAD). Animals were inoculated with OVA (i.p) on day 1 and 14 followed by intranasal challenge on 27th and 29th day. Both extracts of QL at 600, 300 and 150 mg/kg and dexamethasone (2 mg/kg) l were administered consecutively from days 15–26 via oral gavage. The QL extracts notably reduced (p < 0.0001-p < 0.05) total and differential leukocyte counts in blood and BALF and serum IgE levels in contrast to disease control. Both extracts and Dex substantially improved activities of superoxide dismutase, catalase, and GSH, while reduced malondialdehyde level in treated mice. Treatment with extracts and Dex caused significant (p < 0.0001-p < 0.05) downregulation of tumor necrosis factor-α, interleukin-4, − 5, − 13, − 6, − 1β, and NF-κB whereas, increased expression of Aquaporin (AQP) 1 and AQP5 in contrast to disease control. It was inferenced from findings that both extract of QL exhibited notable antiasthmatic potential might be due to presence of Daidzein-glucuronic acid, 3-Hydroxyphloretin 6′-hexoside, Catechin, Quercetin, and Kaemferol.

与合成药物相比，由于成本低且副作用相对较小，草药为治疗哮喘等疾病提供了一种替代方法。Quercus leucotrichophora的叶子传统上用于治疗哮喘。该研究旨在评估Quercus leucotrichophora的抗哮喘活性(QL) 甲醇 (QLME) 和水提取物 (QLAE) 在卵白蛋白 (OVA) 诱导的哮喘中以及通过高效液相色谱 - 二极管阵列检测器 (HPLC-DAD) 对 QL 提取物进行化学表征。在第 1 天和第 14 天给动物接种 OVA (ip)，然后在第 27 天和第 29 天鼻内攻击。600、300 和 150 mg/kg 的 QL 提取物和地塞米松 (2 mg/kg) l 从第 15-26 天通过口服管饲法连续给药。与疾病控制相比，QL 提取物显着降低 (p < 0.0001-p < 0.05) 血液和 BALF 中的总和差异白细胞计数以及血清 IgE 水平。提取物和 Dex 都显着提高了超氧化物歧化酶、过氧化氢酶和 GSH 的活性，同时降低了治疗小鼠的丙二醛水平。用提取物和 Dex 处理导致显着（p < 0.0001-p < 0. 05）肿瘤坏死因子-α、白细胞介素-4、-5、-13、-6、-1β和NF-κB的下调，而与疾病控制相比，水通道蛋白（AQP）1和AQP5的表达增加。从研究结果推断，QL 的两种提取物都表现出显着的平喘潜力，这可能是由于黄豆苷元-葡萄糖醛酸、3-羟基根皮素 6'-己糖苷、儿茶素、槲皮素和山柰酚的存在。