Influence of homeostatic mechanisms of bacterial growth and division on structural properties of microcolonies: A computer simulation study,Physical Review E

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Influence of homeostatic mechanisms of bacterial growth and division on structural properties of microcolonies: A computer simulation study
Physical Review E ( IF 2.2 ) Pub Date : 2022-09-15 , DOI: 10.1103/physreve.106.034402
Andrés Delgado-Campos ₁ , Alejandro Cuetos ₁

Affiliation

Bacterial growth and division generally occur by the process known as binary fission, in which the cells grow polarly until they divide into two daughter cells. Although this process is affected by factors that introduce stochastic variability in both growth rate and daughter cell length, the fact is that the size distribution in growing bacteria remains stable over time. This suggests the existence of homeostatic mechanisms that contribute to maintaining a stable size distribution. Those known as sizer and adder stand out among these mechanisms whose relevance is not entirely determined. In this work, computer simulations using an agent-based model are used to study the effect of these homeostatic mechanisms on the geometrical and structural properties of the developing microcolonies, focusing on the early stages of its development. Also, we examine the effect of linear or exponential dependence with the time of cellular growth on these properties. From our study, we deduce that these mechanisms do not have a noticeable impact on the properties studied, which could be due to the importance that stochastic factors play in the cell division and growth process. In addition, we discuss how competition between cell growth and diffusion is a key aspect in explaining the structure and geometry of developing bacterial microcolonies. The results of the study will help to clarify which processes and parameters should be considered relevant when designing simulation models.

中文翻译：

细菌生长和分裂的稳态机制对微菌落结构特性的影响：计算机模拟研究

细菌的生长和分裂通常通过称为二元裂变的过程发生，其中细胞极性生长，直到它们分裂成两个子细胞。尽管这一过程受到在生长速率和子细胞长度中引入随机变异性的因素的影响，但事实是生长细菌中的大小分布随时间保持稳定。这表明存在有助于维持稳定的尺寸分布的稳态机制。那些被称为 sizer 和 adder 的机制在这些机制中脱颖而出，它们的相关性尚未完全确定。在这项工作中，使用基于代理的模型的计算机模拟用于研究这些稳态机制对发育中的微菌落的几何和结构特性的影响，重点关注其发展的早期阶段。还，我们研究了细胞生长时间对这些特性的线性或指数依赖性的影响。从我们的研究中，我们推断这些机制对所研究的特性没有显着影响，这可能是由于随机因素在细胞分裂和生长过程中的重要性。此外，我们讨论了细胞生长和扩散之间的竞争如何成为解释发育中的细菌微菌落的结构和几何形状的关键方面。研究结果将有助于阐明在设计仿真模型时应考虑哪些过程和参数是相关的。这可能是由于随机因素在细胞分裂和生长过程中的重要性。此外，我们讨论了细胞生长和扩散之间的竞争如何成为解释发育中的细菌微菌落的结构和几何形状的关键方面。研究结果将有助于阐明在设计仿真模型时应考虑哪些过程和参数是相关的。这可能是由于随机因素在细胞分裂和生长过程中的重要性。此外，我们讨论了细胞生长和扩散之间的竞争如何成为解释发育中的细菌微菌落的结构和几何形状的关键方面。研究结果将有助于阐明在设计仿真模型时应考虑哪些过程和参数是相关的。

更新日期：2022-09-15

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