Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK-9 Concentrations in Healthy Subjects in a Double-Blind, Randomized, Active-Controlled, Crossover Trial,Molecular Nutrition & Food Research

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Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK-9 Concentrations in Healthy Subjects in a Double-Blind, Randomized, Active-Controlled, Crossover Trial
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-09-13 , DOI: 10.1002/mnfr.202200139
Juergen Grafeneder ₁ , Ulla Derhaschnig ₂ , Farsad Eskandary ₃ , Nina Buchtele ₄ , Nadine Sus ₅ , Jan Frank ₅ , Bernd Jilma ₂ , Christian Schoergenhofer ₂

Affiliation

Scope: Preclinical models have demonstrated the anti-inflammatory and lipid-lowering effects of curcumin. Innovative formulations have been developed to overcome the poor bioavailability of native curcumin. The study hypothesizes that the bioavailability of micellar curcumin is superior to native curcumin and investigates the potential anti-inflammatory and proprotein convertase subtilisin/kexin type 9 (PCSK9) concentration lowering effects.

中文翻译：

胶束姜黄素：双盲、随机、主动对照、交叉试验中健康受试者的药代动力学及其对炎症标志物和 PCSK-9 浓度的影响

范围：临床前模型已证明姜黄素具有抗炎和降脂作用。我们开发了创新配方来克服天然姜黄素生物利用度差的问题。该研究假设胶束姜黄素的生物利用度优于天然姜黄素，并研究了潜在的抗炎作用和前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 浓度降低作用。

更新日期：2022-09-13

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