The aim of this study is to evaluate the changes in myocardial functions in children who underwent haematopoietic stem cell transplantation along with associated chemotherapy. Additionally, we evaluated the effect of baseline echocardiographic parameters on mortality. We evaluated 39 patients (mean age 7.4 years) who underwent haematopoietic stem cell transplantation owing to non-malignant disease. The control group included 39 healthy children who had normal cardiac findings. The myocardial functions were evaluated in all subjects by conventional echocardiography and tissue Doppler echocardiography before haematopoietic stem cell transplantation and in the 1st, 3rd, 6th, and 12th month after haematopoietic stem cell transplantation. All patients had normal left ventricular ejection fraction before haematopoietic stem cell transplantation, except one case. Before haematopoietic stem cell transplantation, the patient group had significantly greater mean pulmonary artery pressure and lower tricuspid valve annular plane excursion rate. Baseline E’ velocities for mitral lateral annuli, septum, and tricuspid lateral annuli were lower in the patient group than the control group. The E’ velocities for the left ventricle decreased in the patient group after haematopoietic stem cell transplantation, and then returned to baseline levels at the 6 months. E’ and S’ velocities for tricuspid lateral annuli also decreased after haematopoietic stem cell transplantation and were still depressed in the first year after haematopoietic stem cell transplantation. Baseline E’ velocity for septum was significantly lower in patients who died after haematopoietic stem cell transplantation than patients who survived (p = 0.009). Subclinical impairment in both ventricular functions was observed after haematopoietic stem cell transplantation and the right ventricular functions were affected for longer periods than left ventricle after haematopoietic stem cell transplantation. The myocardial functions should be monitored after the first year of haematopoietic stem cell transplantation.

本研究的目的是评估接受造血干细胞移植和相关化疗的儿童心肌功能的变化。此外，我们评估了基线超声心动图参数对死亡率的影响。我们评估了 39 名因非恶性肿瘤而接受造血干细胞移植的患者（平均年龄 7.4 岁）。对照组包括 39 名心脏检查结果正常的健康儿童。造血干细胞移植前及造血干细胞移植后第1、3、6、12个月均采用常规超声心动图和组织多普勒超声心动图评价所有受试者的心肌功能。除1例外，所有患者在造血干细胞移植前左心室射血分数均正常。造血干细胞移植前，患者组平均肺动脉压明显较高，三尖瓣环平面偏移率较低。患者组二尖瓣外侧环、隔膜和三尖瓣外侧环的基线 E' 速度低于对照组。造血干细胞移植后患者组左心室E'速度下降，然后在6个月时恢复到基线水平。三尖瓣外侧环的 E' 和 S' 速度在造血干细胞移植后也下降，并且在造血干细胞移植后第一年仍然下降。造血干细胞移植后死亡患者的隔膜基线 E' 速度显着低于存活患者 (p = 0.009)。造血干细胞移植后观察到双心室功能亚临床损害，且造血干细胞移植后右心室功能受影响的时间长于左心室。造血干细胞移植第一年后应监测心肌功能。