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Individual and mixture associations of perfluoroalkyl substances on liver function biomarkers in the Canadian Health Measures Survey
Environmental Health ( IF 5.3 ) Pub Date : 2022-09-14 , DOI: 10.1186/s12940-022-00892-6
Michael M Borghese 1 , Chun Lei Liang 1 , James Owen 1 , Mandy Fisher 1
Affiliation  

Perfluoroalkyl substances can disrupt hepatic metabolism and may be associated with liver function biomarkers. We examined individual and mixture associations of PFAS on liver function biomarkers in a representative sample of Canadian adults. We explored the potential for effect modification by sex and body mass index, as well as by physical activity level which may attenuate the deleterious effect of PFAS on metabolic disorders. We analyzed data from participants aged 20–74 from the Canadian Health Measures Survey. We used linear regression to examine associations between plasma concentrations of PFOA, PFOS, PFHxS, PFNA, PFDA, and PFUDA on serum concentrations of aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and total bilirubin. We used quantile g-computation to estimate associations with a PFAS mixture for each simultaneous, one-quartile change in PFAS concentrations. Each doubling of PFOA, PFOS, PFHxS, or PFNA concentrations was associated with higher AST, GGT, and ALP concentrations. Each doubling of PFOA concentrations was associated with 16.5% (95%CI: 10.4, 23.0) higher GGT concentrations among adults not meeting Canada’s physical activity guidelines vs. 6.6% (95%CI: -1.6, 15.5) among those meeting these guidelines. Sex and BMI also modified some associations, though to a lesser extent. We did not observe associations between ALT and PFOA (1.2% change; 95%CI: -2.5, 4.9), PFOS (2.2% change; 95%CI: -0.8, 5.3), or PFHxS (1.5% change; 95%CI: -0.4, 3.4). We also did not observe consistent associations for PFDA and PFUDA or with total bilirubin. In quantile g-computation models, each simultaneous one-quartile increase in the PFAS mixture was positively associated with AST (7.5% higher; 95%CI: 4.0, 10.4), GGT (9.7% higher; 95%CI: 1.7, 17.0), and ALP (2.8% higher; 95%CI: 0.5, 5.4). Higher plasma concentrations of PFOA, PFOS, PFHxS, and PFNA – both individually and as a mixture – were associated with higher serum concentrations of liver function biomarkers. These results contribute to emerging evidence suggesting that higher levels of physical activity appear to be protective against the hepatotoxic effects of PFOA. This work contributes to a growing body of evidence supporting the hepatotoxic effects of PFAS.

中文翻译:

加拿大健康措施调查中全氟烷基物质对肝功能生物标志物的个体和混合物关联

全氟烷基物质会破坏肝脏代谢,并可能与肝功能生物标志物有关。我们在加拿大成年人的代表性样本中检查了 PFAS 与肝功能生物标志物的个体和混合物关联。我们探索了通过性别和体重指数以及可能减弱 PFAS 对代谢紊乱的有害影响的身体活动水平来改变影响的可能性。我们分析了来自加拿大健康措施调查的 20-74 岁参与者的数据。我们使用线性回归来检查 PFOA、PFOS、PFHxS、PFNA、PFDA 和 PFUDA 血浆浓度与天冬氨酸氨基转移酶 (AST)、γ-谷氨酰转移酶 (GGT)、碱性磷酸酶 (ALP)、丙氨酸氨基转移酶 (ALT) 血清浓度之间的关联) 和总胆红素。我们使用分位数 g 计算来估计 PFAS 浓度的每个同时发生的四分之一变化与 PFAS 混合物的关联。PFOA、PFOS、PFHxS 或 PFNA 浓度每增加一倍都与更高的 AST、GGT 和 ALP 浓度相关。PFOA 浓度每增加一倍,在不符合加拿大体育活动指南的成年人中,GGT 浓度每增加 16.5%(95%CI:10.4,23.0),而在符合这些指南的成年人中,GGT 浓度为 6.6%(95%CI:-1.6,15.5)。性别和 BMI 也改变了一些关联,尽管程度较小。我们没有观察到 ALT 和 PFOA(1.2% 变化;95%CI:-2.5、4.9)、PFOS(2.2% 变化;95%CI:-0.8、5.3)或 PFHxS(1.5% 变化;95%CI)之间的关联:-0.4,3.4)。我们也没有观察到 PFDA 和 PFUDA 或与总胆红素的一致关联。在分位数 g 计算模型中,PFAS 混合物同时增加一个四分位数与 AST(高 7.5%;95%CI:4.0、10.4)、GGT(高 9.7%;95%CI:1.7、17.0)呈正相关和 ALP(高 2.8%;95%CI:0.5、5.4)。PFOA、PFOS、PFHxS 和 PFNA 的血浆浓度较高(无论是单独还是作为混合物)与肝功能生物标志物的血清浓度较高有关。这些结果有助于新出现的证据表明,更高水平的身体活动似乎可以防止 PFOA 的肝毒性作用。这项工作有助于提供越来越多的证据支持 PFAS 的肝毒性作用。高出 8%;95%CI:0.5、5.4)。PFOA、PFOS、PFHxS 和 PFNA 的血浆浓度较高(无论是单独还是作为混合物)与肝功能生物标志物的血清浓度较高有关。这些结果有助于新出现的证据表明,更高水平的身体活动似乎可以防止 PFOA 的肝毒性作用。这项工作有助于提供越来越多的证据支持 PFAS 的肝毒性作用。高出 8%;95%CI:0.5、5.4)。PFOA、PFOS、PFHxS 和 PFNA 的血浆浓度较高(无论是单独还是作为混合物)与肝功能生物标志物的血清浓度较高有关。这些结果有助于新出现的证据表明,更高水平的身体活动似乎可以防止 PFOA 的肝毒性作用。这项工作有助于提供越来越多的证据支持 PFAS 的肝毒性作用。
更新日期:2022-09-14
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