DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice,Molecular Nutrition & Food Research

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DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-09-13 , DOI: 10.1002/mnfr.202200275
Xueyan Wang ₁ , Aiai Xiao ₁ , Yueqi Yang ₁ , Yingcai Zhao ₂ , Cheng Cheng Wang ₂ , Yuming Wang ₂ , Jun Han ₁ , Zhengping Wang ₁ , Min Wen _{1,

3}

Affiliation

It has been reported that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anticonvulsant effects, yet the respective mechanism of EPA and DHA on epilepsy is still unclarified. This study aims to investigate the effect of EPA and DHA on pentylenetetrazol (PTZ) induced seizures and depression.

中文翻译：

在戊四唑诱导的小鼠点燃模型中，DHA 和 EPA 通过不同的作用模式抑制铁死亡和神经炎症，从而预防癫痫发作和抑郁样行为

据报道，二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）具有抗惊厥作用，但EPA和DHA各自对癫痫的作用机制尚不清楚。本研究旨在研究 EPA 和 DHA 对戊四氮 (PTZ) 诱发的癫痫发作和抑郁症的影响。

更新日期：2022-09-13

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