Background

Nitrogen sources play an essential role in maintaining the physiological and biochemical activity of bacteria. Nitrogen metabolism, which is the core of microorganism metabolism, makes bacteria able to autonomously respond to different external nitrogen environments by exercising complex internal regulatory networks to help them stay in an ideal state. Although various studies have been put forth to better understand this regulation in Bacillus, and many valuable viewpoints have been obtained, these views need to be presented systematically and their possible applications need to be specified.

Aim of review

The intention is to provide a deep and comprehensive understanding of nitrogen metabolism in Bacillus, an important industrial microorganism, and thereby apply this regulatory logic to synthetic biology to improve biosynthesis competitiveness. In addition, the potential researches in the future are also discussed.

Key scientific concept of review

Understanding the meticulous regulation process of nitrogen metabolism in Bacillus not only could facilitate research on metabolic engineering but also could provide constructive insights and inspiration for studies of other microorganisms.

中文翻译：

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芽孢杆菌氮调节的理解和应用：合成生物学的视角

背景

氮源对于维持细菌的生理生化活性起着至关重要的作用。氮代谢是微生物代谢的核心，它使细菌能够通过复杂的内部调节网络自主响应不同的外部氮环境，帮助其保持在理想状态。尽管为了更好地理解芽孢杆菌中的这种调节已经进行了各种研究，并获得了许多有价值的观点，但这些观点需要系统地提出，并且需要具体说明它们可能的应用。

审查目的

目的是提供对重要工业微生物芽孢杆菌氮代谢的深入、全面的了解，从而将这种调控逻辑应用于合成生物学，提高生物合成竞争力。此外，还讨论了未来的潜在研究。

审查的关键科学概念

了解芽孢杆菌氮代谢的精细调控过程不仅可以促进代谢工程的研究，而且可以为其他微生物的研究提供建设性的见解和启发。