Basal ganglia engagement during REM sleep movements in Parkinson’s disease,npj Parkinson's Disease

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Basal ganglia engagement during REM sleep movements in Parkinson’s disease
npj Parkinson's Disease ( IF 6.7 ) Pub Date : 2022-09-12 , DOI: 10.1038/s41531-022-00382-z
Ajay K Verma ₁ , Sergio Francisco Acosta Lenis ₁ , Joshua E Aman ₁ , David Escobar Sanabria ₁ , Jing Wang ₁ , Amy Pearson ₁ , Meghan Hill ₁ , Remi Patriat ₂ , Lauren E Schrock ₁ , Scott E Cooper ₁ , Michael C Park _{1,

3} , Noam Harel _{2,

3} , Michael J Howell ₁ , Colum D MacKinnon ₁ , Jerrold L Vitek ₁ , Luke A Johnson ₁

Affiliation

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150–350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

中文翻译：

帕金森病快速眼动睡眠运动期间基底神经节的参与

为了阐明基底神经节在帕金森病 (PD) 快速眼动睡眠运动中的作用，我们记录了四名帕金森病患者的苍白球神经活动。与清醒运动期间常见的去同步不同，β 振荡（13-35 Hz）在快速眼动睡眠运动期间是同步的；此外，无论睡眠-觉醒状态如何，运动过程中都会同步高频振荡（150-350 Hz）。我们的结果证明了基底神经节在快速眼动睡眠和清醒运动期间的不同参与。

更新日期：2022-09-12

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