Comprehensive analysis of ferroptosis in Hepatocellular Carcinoma (HCC) and its relation to the tumor immune microenvironment are needed. Data included HCC in The Cancer Genome Atlas and International Cancer Genome Consortium. And two datasets from Gene Expression Omnibus (GEO) were used as the validation set. Based on the expression of ferroptosis-related genes, HCC patients were divided into two subtypes. Cluster 1 showed lower tumor grade, lower CTLA-4, and a more favorable prognosis than Cluster 2. Patients with higher SLC7A11 (50%) had a poorer prognosis in HCC. SLC7A11 is characterized by more NK CD56bright cells, less DC, and neuroactive ligand–receptor interaction and cytokine receptor interaction. Ferroptosis-related genes especially SLC7A11 might be a valuable prognostic factor in HCC.

需要对肝细胞癌 (HCC) 中的铁死亡及其与肿瘤免疫微环境的关系进行综合分析。数据包括癌症基因组图谱和国际癌症基因组联盟中的 HCC。来自 Gene Expression Omnibus (GEO) 的两个数据集被用作验证集。基于铁死亡相关基因的表达，HCC患者分为两种亚型。聚类 1 显示较低的肿瘤分级、较低的 CTLA-4 和比聚类 2 更有利的预后。具有较高SLC7A11 (50%) 的患者在 HCC 中的预后较差。SLC7A11其特点是更多的 NK CD56bright 细胞，更少的 DC，以及神经活性配体-受体相互作用和细胞因子受体相互作用。铁死亡相关基因，尤其是 SLC7A11 可能是 HCC 中一个有价值的预后因素。