当前位置: X-MOL 学术Hepatology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology ( IF 12.9 ) Pub Date : 2022-09-11 , DOI: 10.1002/hep.32781
Jack Leslie 1 , Jill E Hunter 2 , Amy Collins 1 , Amelia Rushton 1 , Lauren G Russell 2 , Erik Ramon-Gil 1 , Maja Laszczewska 1 , Misti McCain 3 , Marco Y W Zaki 1, 4 , Amber Knox 1 , Yixin Seow 1 , Laura Sabater 1 , Daniel Geh 1, 5 , Neil D Perkins 2 , Helen L Reeves 3, 5 , Dina Tiniakos 3, 6 , Derek A Mann 1 , Fiona Oakley 1
Affiliation  

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. The NF-κB transcription factor family subunit c-Rel is typically protumorigenic; however, it has recently been reported as a tumor suppressor. Here, we investigated the role of c-Rel in HCC.

中文翻译:


c-Rel 依赖性 Chk2 信号传导调节 DNA 损伤反应,限制肝癌发生



肝细胞癌(HCC)是癌症相关死亡的主要原因。 NF-κB 转录因子家族亚基 c-Rel 通常具有促肿瘤作用;然而,最近有报道称它是一种肿瘤抑制剂。在这里,我们研究了 c-Rel 在 HCC 中的作用。
更新日期:2022-09-11
down
wechat
bug