T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease.,Journal of the Pediatric Infectious Diseases Society

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T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease.
Journal of the Pediatric Infectious Diseases Society ( IF 2.5 ) Pub Date : 2022-12-28 , DOI: 10.1093/jpids/piac092
Marc Jacobsen ₁ , Jonathan Kofi Adjei ₂ , Wilfred Aniagyei ₂ , Ernest Adankwah _{2,

3} , Julia Seyfarth ₁ , Ertan Mayatepek ₁ , Daniel Antwi-Berko ₂ , Samuel Asamoah Sakyi ₄ , Alexander Y Debrah ₂ , Linda Batsa Debrah ₂ , Dorcas O Owusu ₂ , Richard O Phillips _{2,

5}

Affiliation

Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.

中文翻译：

针对溃疡分枝杆菌和结核分枝杆菌蛋白提取物的 T 细胞反应可识别患有布鲁里溃疡病的儿童。

由于分枝杆菌之间的交叉反应，很难对儿童布鲁里溃疡病 (BUD) 进行基于免疫的诊断。我们发现 T 细胞 IFNγ/TNFα 对溃疡分枝杆菌 (M.) 和结核分枝杆菌 (PPDMulc, PPDMtub) 的反应在患有 BUD (n = 27) 和 TB (n = 20) 的儿童之间是不同的，但只是比率 (PPDMtub/ PPDMulc) 有效地区分了研究组。

更新日期：2022-09-07

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