Background: Nicorandil will activate ATP-sensitive potassium channel (KATP). However, activation of potassium channels plays an important role in the mechanism of atrial fibrillation (AF) or atrial flutter (AFL). Whether use of nicorandil might contribute to initiation and/or perpetuation of AF/AFL remained unknown. We determined the relationship between use of nicorandil and risk of atrial fibrillation and determined its molecular mechanism.

中文翻译：

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使用尼可地尔会增加房颤的风险

背景：尼可地尔会激活 ATP 敏感性钾通道 (KATP)。然而，钾通道的激活在心房颤动 (AF) 或心房扑动 (AFL) 的机制中起着重要作用。使用尼可地尔是否会导致 AF/AFL 的发生和/或持续仍然未知。我们确定了尼可地尔的使用与房颤风险之间的关系，并确定了其分子机制。