Chronic lymphocytic leukemia (CLL) is the most common incurable leukemia/lymphoma in the United States. Individuals with CLL are at risk for disability, frailty, and cancer-specific complications that negatively affect health-related quality of life (HRQOL). High-intensity interval training (HIIT) and resistance training (RT) are safe and feasible for individuals with chronic diseases and when combined, they may be beneficial for reducing cancer-related fatigue, symptom burden, and global quality of life. However, no studies have examined the impact of HIIT or RT on HRQOL in CLL. The purpose of this study was to investigate the effects of a 12-week HIIT and RT (HIIT+RT) intervention on HRQOL in adults with treatment naïve CLL. Changes in HRQOL was a secondary outcome in this pilot study. Individuals with CLL (63.9 ± 8.5 yrs) were non-randomly assigned to 12 weeks of HIIT+RT or a control group. The HIIT+RT protocol consisted of three 30-min sessions/week of HIIT and two sessions/week of RT. The control group maintained usual daily activities. We assessed pre and post HRQOL using the Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym) questionnaire with domains of physical (PWB), social (SWB), emotional (EWB), functional (FWB), and general (FACT-G) well-being as well as a lymphoma-specific subscale (LymS). We used a two-way mixed analysis of variance to assess changes in HRQOL. We calculated effect size (ES) using Cohen's . Fifteen participants (HIIT+RT: = 9; Control: = 6) completed the study and questionnaire. Scores for FWB improved following HIIT+RT (21.7 ± 3.4 to 23.9 ± 3.2; ES = 1.38) compared to controls (25.7 ± 2.2 to 25.7 ± 2.3). The HIIT+RT group experienced clinically meaningful improvements in total FACT-Lym, FWB, FACT-G, and LymS. The control group had clinically meaningful changes only in LymS. The large effect sizes and clinically meaningful improvements associated with 12 weeks of HIIT+RT support the potential benefits of this type of exercise program for FWB, lymphoma-specific symptoms, and general well-being in CLL. A future randomized trial with an adequately powered sample size is needed to evaluate these findings.

中文翻译：

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高强度间歇训练对慢性淋巴细胞白血病健康相关生活质量的影响：一项初步研究


慢性淋巴细胞白血病（CLL）是美国最常见的无法治愈的白血病/淋巴瘤。 CLL 患者面临残疾、虚弱和癌症特异性并发症的风险，这些并发症会对健康相关的生活质量 (HRQOL) 产生负面影响。高强度间歇训练 (HIIT) 和阻力训练 (RT) 对于慢性病患者来说是安全可行的，结合起来可能有利于减少与癌症相关的疲劳、症状负担和总体生活质量。然而，尚无研究探讨 HIIT 或 RT 对 CLL 患者 HRQOL 的影响。本研究的目的是调查 12 周 HIIT 和 RT (HIIT+RT) 干预对初治 CLL 成人患者 HRQOL 的影响。 HRQOL 的变化是该试点研究的次要结果。 CLL 患者（63.9 ± 8.5 岁）被非随机分配到 12 周 HIIT+RT 组或对照组。 HIIT+RT 方案包括每周 3 次每次 30 分钟的 HIIT 课程和每周 2 次 RT 课程。对照组维持正常的日常活动。我们使用癌症治疗-淋巴瘤功能评估 (FACT-Lym) 问卷评估前后的 HRQOL，包括身体 (PWB)、社交 (SWB)、情感 (EWB)、功能 (FWB) 和一般 (FACT-G) 领域) 健康状况以及淋巴瘤特异性分量表 (LymS)。我们使用双向混合方差分析来评估 HRQOL 的变化。我们使用 Cohen 计算了效应量 (ES)。 15 名参与者（HIIT+RT：= 9；对照：= 6）完成了研究和问卷调查。与对照组相比（25.7 ± 2.2 至 25.7 ± 2.3），HIIT+RT 后 FWB 得分有所改善（21.7 ± 3.4 至 23.9 ± 3.2；ES = 1.38）。 HIIT+RT 组在总 FACT-Lym、FWB、FACT-G 和 LymS 方面经历了具有临床意义的改善。 对照组仅 LymS 发生有临床意义的变化。与 12 周 HIIT+RT 相关的巨大效果和具有临床意义的改善支持了此类运动计划对 FWB、淋巴瘤特异性症状和 CLL 总体健康的潜在益处。未来需要进行具有足够样本量的随机试验来评估这些发现。