Background and Hypothesis The idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Manifestations of the self-disorder can be systematically explored with the Examination of Anomalous Self-Experience (EASE). In this study, we examined the factorial structure of EASE, and diagnostic efficacy of EASE. We hypothesized that EASE will have a monofactorial structure as an instability of the basic self will result in multiple deformations of self-experience which would be meaningfully interrelated as aspects of a unifying Gestalt. Design EASE data for 226 patients suffering from various mental disorders were analyzed under a confirmatory factor analysis framework (CFA). Area under the receiver operating characteristic curve (AUC) was calculated for the total EASE sums, and sensitivity and specificity values for prediction of schizophrenia spectrum disorders based on different cut-offs were obtained. Results Fit indices for the CFA model: RMSEA = 0.036, SRMR = 0.100, CFI = 0.983, TLI = 0.981. The AUC value was 0.946 (95% confidence interval: 0.919–0.974). Sensitivity as well as specificity for schizophrenia spectrum disorders were high. Conclusion Our results lend support for EASE exhibiting a monofactorial structure and the notion of self-disorders as a central phenotypic feature of schizophrenia spectrum disorders.

中文翻译：

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精神分裂症中的自我障碍是否表达了主观性的统一障碍：一种因素分析方法

背景和假设 基本自我障碍是精神分裂症的核心特征这一观点最近在荟萃分析和系统评价中得到证实。可以通过异常自我体验检查 (EASE) 系统地探索自我障碍的表现。在这项研究中，我们检查了 EASE 的阶乘结构和 EASE 的诊断功效。我们假设 EASE 将具有单因素结构，因为基本自我的不稳定性将导致自我体验的多重变形，这些变形将作为统一格式塔的各个方面有意义地相互关联。在验证性因素分析框架 (CFA) 下分析了 226 名患有各种精神障碍的患者的设计 EASE 数据。计算总 EASE 总和的接受者操作特征曲线 (AUC) 下的面积，并获得基于不同截止值预测精神分裂症谱系障碍的灵敏度和特异性值。结果 CFA 模型的拟合指数：RMSEA = 0.036，SRMR = 0.100，CFI = 0.983，TLI = 0.981。AUC 值为 0.946（95% 置信区间：0.919–0.974）。精神分裂症谱系障碍的敏感性和特异性都很高。结论 我们的结果支持 EASE 表现出单因素结构和自我障碍的概念作为精神分裂症谱系障碍的主要表型特征。SRMR = 0.100，CFI = 0.983，TLI = 0.981。AUC 值为 0.946（95% 置信区间：0.919–0.974）。精神分裂症谱系障碍的敏感性和特异性都很高。结论 我们的结果支持 EASE 表现出单因素结构和自我障碍的概念作为精神分裂症谱系障碍的主要表型特征。SRMR = 0.100，CFI = 0.983，TLI = 0.981。AUC 值为 0.946（95% 置信区间：0.919–0.974）。精神分裂症谱系障碍的敏感性和特异性都很高。结论 我们的结果支持 EASE 表现出单因素结构和自我障碍的概念作为精神分裂症谱系障碍的主要表型特征。