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The general law of plasma proteome alterations occurring in the lifetime of Chinese individuals reveals the importance of immunity
Aging-US ( IF 5.2 ) Pub Date : 2022-09-07 , DOI: 10.18632/aging.204278 Xiaolin Ni 1, 2, 3 , Juan Jiao 4 , Ze Yang 1 , Zhaoping Wang 1 , Nan Nan 5 , Danni Gao 1 , Liang Sun 1 , Xiaoquan Zhu 1 , Qi Zhou 1 , Nan Zhang 1 , Zhu Wu 1 , Shenqi Zhang 6 , Huiping Yuan 1
Aging-US ( IF 5.2 ) Pub Date : 2022-09-07 , DOI: 10.18632/aging.204278 Xiaolin Ni 1, 2, 3 , Juan Jiao 4 , Ze Yang 1 , Zhaoping Wang 1 , Nan Nan 5 , Danni Gao 1 , Liang Sun 1 , Xiaoquan Zhu 1 , Qi Zhou 1 , Nan Zhang 1 , Zhu Wu 1 , Shenqi Zhang 6 , Huiping Yuan 1
Affiliation
Background: Aging is characterized by a continuous loss of protein homeostasis. A closer examination of peripheral blood, which houses proteins from nearly all tissues and cells, helped identify several biomarkers and other aspects of aging biology. To further explore the general law of aging and identify key time nodes and associated aging biology, we collected 97 plasma samples from 253 healthy individuals aged 0-100 years without adverse outcomes to conduct nano-Ultra High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (nano-UHPLC-MS/MS) and weighted gene co-expression network analysis (WGCNA).
更新日期：2022-09-07
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