Azithromycin (AZI) belongs to the class of macrolide antibiotics that has limited water solubility and belongs to Biopharmaceutical Classification System Class II. Dissolution is the rate-limiting step in the absorption process of AZI. Several approaches have been investigated for enhancing the bioavailability of poorly soluble drugs. This review intends to explore the various strategies that have been investigated for improving the solubility and/or bioavailability of AZI and the delivery systems that have been designed for delivery of AZI in ocular fluid.

中文翻译：

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阿奇霉素递送和生物利用度增强策略综述

阿奇霉素（AZI）属于大环内酯类抗生素，水溶性有限，属于生物制药分类系统II类。溶解是AZI吸收过程中的限速步骤。已经研究了几种方法来提高难溶性药物的生物利用度。本综述旨在探索已研究的各种策略，以提高 AZI 的溶解度和/或生物利用度，以及设计用于在眼液中递送 AZI 的递送系统。