The global prevalence of cancer is increasing, necessitating new additions to traditional treatments and diagnoses to address shortcomings such as ineffectiveness, complications, and high cost. In this context, nano and microparticulate carriers stand out due to their unique properties such as controlled release, higher bioavailability, and lower toxicity. Despite their popularity, they face several challenges including rapid liver uptake, low chemical stability in blood circulation, immunogenicity concerns, and acute adverse effects. Cell-mediated delivery systems are important topics to research because of their biocompatibility, biodegradability, prolonged delivery, high loading capacity, and targeted drug delivery capabilities. To date, a variety of cells including blood, immune, cancer, and stem cells, sperm, and bacteria have been combined with nanoparticles to develop efficient targeted cancer delivery or diagnosis systems. The review paper aimed to provide an overview of the potential applications of cell-based delivery systems in cancer therapy and diagnosis.

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用于癌症治疗和诊断的基于纳米技术的细胞介导递送系统

癌症的全球患病率正在上升，传统治疗和诊断需要新的补充，以解决无效、并发症和高成本等缺点。在这种情况下，纳米和微粒载体因其独特的特性而脱颖而出，例如控释、更高的生物利用度和更低的毒性。尽管它们很受欢迎，但它们面临着几个挑战，包括快速的肝脏吸收、血液循环中的化学稳定性低、免疫原性问题和急性副作用。细胞介导的递送系统是重要的研究课题，因为它们具有生物相容性、生物可降解性、延长递送时间、高负载能力和靶向药物递送能力。迄今为止，各种细胞包括血液、免疫、癌症和干细胞、精子、和细菌已与纳米粒子相结合，以开发有效的靶向癌症递送或诊断系统。该评论文章旨在概述基于细胞的递送系统在癌症治疗和诊断中的潜在应用。

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