Polybrominated diphenyl ethers (PBDEs) are flame-retardant compounds widely used in household products until phase out in 2004. PBDEs are endocrine disruptors and are suggested to influence signaling related to weight control. Prenatal exposures to PBDEs may alter childhood adiposity, yet few studies have examined these associations in human populations. Data were collected from a birth cohort of Dominican and African American mother-child pairs from New York City recruited from 1998 to 2006. PBDE congeners BDE-47, − 99, − 100, and − 153 were measured in cord plasma (ng/μL) and dichotomized into low (< 80th percentile) and high (>80th percentile) exposure categories. Height and weight were collected at ages 5, 7, 9, 11, and an ancillary visit from 8 to 14 years (n = 289). Mixed-effects models with random intercepts for participant were used to assess associations between concentrations of individual PBDE congeners or the PBDE sum and child BMI z-scores (BMIz). To assess associations between PBDEs and the change in BMIz over time, models including interactions between PBDE categories and child age and (child age)2 were fit. Quantile g-computation was used to investigate associations between BMIz and the total PBDE mixture. Models were adjusted for baseline maternal covariates: ethnicity, age, education, parity, partnership status, and receipt of public assistance, and child covariates: child sex and cord cholesterol and triglycerides. The prevalence of children with obesity at age 5 was 24.2% and increased to 30% at age 11. Neither cord levels of individual PBDEs nor the total PBDE mixture were associated with overall BMIz in childhood. The changes in BMIz across childhood were not different between children with low or high PBDEs. Results were similar when adjusting for postnatal PBDE exposures. Prenatal PBDE exposures were not associated with child growth trajectories in a cohort of Dominican and African American children.

中文翻译：

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产前接触多溴二苯醚和 5 至 14 岁的 BMI Z 值

多溴二苯醚 (PBDE) 是一种阻燃化合物，广泛用于家用产品，直到 2004 年才被淘汰。PBDE 是内分泌干扰物，被认为会影响与体重控制相关的信号。产前接触多溴二苯醚可能会改变儿童期肥胖，但很少有研究在人群中检验过这些关联。数据收集自 1998 年至 2006 年从纽约市招募的多米尼加和非洲裔美国母子对的出生队列。多溴二苯醚同源物 BDE-47、− 99、− 100 和 − 153 在脐带血浆中测量（ng/μL ) 并分为低（< 80%）和高（> 80%）暴露类别。在 5、7、9、11 岁时收集身高和体重数据，并在 8 至 14 岁时进行辅助访问（n = 289）。使用随机截取参与者的混合效应模型来评估单个 PBDE 同系物浓度或 PBDE 总和与儿童 BMI z 分数 (BMIz) 之间的关联。为了评估 PBDE 与 BMIz 随时间变化之间的关联，拟合了包括 PBDE 类别与儿童年龄和（儿童年龄）2 之间相互作用的模型。分位数 g 计算用于研究 BMIz 与总 PBDE 混合物之间的关联。模型针对基线母体协变量进行了调整：种族、年龄、教育、胎次、伴侣关系状态和接受公共援助，以及儿童协变量：儿童性别和脐带胆固醇和甘油三酯。5 岁时肥胖儿童的患病率为 24.2%，11 岁时增加到 30%。单个多溴二苯醚的脐带水平和总多溴二苯醚混合物均与儿童时期的整体 BMIz 无关。儿童时期 BMIz 的变化在 PBDEs 低或高的儿童之间没有差异。调整产后 PBDE 暴露后的结果相似。在一组多米尼加和非裔美国儿童中，产前 PBDE 暴露与儿童生长轨迹无关。