To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes. Data from the Vitamin D Effects on Osteoarthritis (VIDEO) study were analyzed as a cohort. The Western Ontario and McMaster Universities Osteoarthritis Index was used to assess knee symptoms at baseline and follow-up. Osteophytes, cartilage defects, and cartilage volumes were measured using magnetic resonance imaging at baseline. Associations between cartilage morphology and changes in knee symptoms were assessed using linear regression models, and mediation analysis was used to test whether these associations were mediated by osteophytes. A total of 334 participants (aged 50 to 79 years) with symptomatic knee osteoarthritis were included in the analysis. Cartilage defects were significantly associated with change in total knee pain, change in weight-bearing pain, and change in non-weight-bearing pain after adjustment for age, sex, body mass index, and intervention. Cartilage volume was significantly associated with change in weight-bearing pain and change in physical dysfunction after adjustment. Lateral tibiofemoral and patellar osteophyte mediated the associations of cartilage defects with change in total knee pain (49–55%) and change in weight-bearing pain (61–62%) and the association of cartilage volume with change in weight-bearing pain (27–30%) and dysfunction (24–25%). Both cartilage defects and cartilage volume had no direct effects on change in knee symptoms. The significant associations between cartilage morphology and changes in knee symptoms were indirect and were partly mediated by osteophytes.

中文翻译：

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骨赘介导膝骨关节炎患者软骨形态与膝关节症状变化之间的关联

调查软骨缺损和软骨体积与膝关节症状变化之间的关联是否由骨赘介导。来自维生素 D 对骨关节炎的影响 (VIDEO) 研究的数据作为一个队列进行分析。西安大略和麦克马斯特大学骨关节炎指数用于评估基线和随访时的膝关节症状。在基线使用磁共振成像测量骨赘、软骨缺损和软骨体积。使用线性回归模型评估软骨形态与膝关节症状变化之间的关联，并使用中介分析来测试这些关联是否由骨赘介导。共有 334 名患有症状性膝关节骨性关节炎的参与者（年龄 50 至 79 岁）被纳入分析。在调整年龄、性别、体重指数和干预后，软骨缺损与全膝关节疼痛、负重疼痛和非负重疼痛的变化显着相关。软骨体积与负重疼痛的变化和调整后身体功能障碍的变化显着相关。胫股外侧骨赘和髌骨骨赘介导了软骨缺损与全膝关节疼痛（49-55%）和负重疼痛变化（61-62%）的关联，以及软骨体积与负重疼痛变化的关联。 27–30%) 和功能障碍 (24–25%)。软骨缺损和软骨体积对膝关节症状的变化没有直接影响。