The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning,Annals of the New York Academy of Sciences

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The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2022-09-07 , DOI: 10.1111/nyas.14884
Sonja C Vernes _{1,

2} , Paolo Devanna _{1,

2} , Stephen Gareth Hörpel _{1,

2,

3} , Ine Alvarez van Tussenbroek _{1,

2} , Uwe Firzlaff ₃ , Peter Hagoort ₄ , Michael Hiller ₅ , Nienke Hoeksema _{2,

4} , Graham M Hughes ₆ , Ksenia Lavrichenko ₂ , Janine Mengede ₂ , Ariadna E Morales ₅ , Maximilian Wiesmann ₇

Affiliation

Vocal learning, the ability to produce modified vocalizations via learning from acoustic signals, is a key trait in the evolution of speech. While extensively studied in songbirds, mammalian models for vocal learning are rare. Bats present a promising study system given their gregarious natures, small size, and the ability of some species to be maintained in captive colonies. We utilize the pale spear-nosed bat (Phyllostomus discolor) and report advances in establishing this species as a tractable model for understanding vocal learning. We have taken an interdisciplinary approach, aiming to provide an integrated understanding across genomics (Part I), neurobiology (Part II), and transgenics (Part III). In Part I, we generated new, high-quality genome annotations of coding genes and noncoding microRNAs to facilitate functional and evolutionary studies. In Part II, we traced connections between auditory-related brain regions and reported neuroimaging to explore the structure of the brain and gene expression patterns to highlight brain regions. In Part III, we created the first successful transgenic bats by manipulating the expression of FoxP2, a speech-related gene. These interdisciplinary approaches are facilitating a mechanistic and evolutionary understanding of mammalian vocal learning and can also contribute to other areas of investigation that utilize P. discolor or bats as study species.

中文翻译：

淡矛鼻蝙蝠：一种用于声音学习的神经分子和转基因模型

声乐学习，即通过从声学信号中学习而产生改良发声的能力，是语音进化的一个关键特征。虽然对鸣禽进行了广泛研究，但用于声乐学习的哺乳动物模型却很少见。鉴于蝙蝠的群居性质、体积小以及某些物种能够在圈养群落中维持的能力，蝙蝠是一个很有前途的研究系统。我们利用淡矛鼻蝙蝠 ( Phyllostomus discolor) 并报告在建立该物种作为理解声乐学习的易处理模型方面取得的进展。我们采用了跨学科的方法，旨在提供对基因组学（第一部分）、神经生物学（第二部分）和转基因学（第三部分）的综合理解。在第一部分中，我们生成了编码基因和非编码 microRNA 的新的高质量基因组注释，以促进功能和进化研究。在第二部分中，我们追踪了与听觉相关的大脑区域之间的联系，并报告了神经影像学以探索大脑的结构和基因表达模式以突出大脑区域。在第三部分中，我们通过操纵FoxP2的表达创造了第一个成功的转基因蝙蝠, 一种与言语相关的基因。这些跨学科的方法正在促进对哺乳动物发声学习的机制和进化的理解，并且还有助于利用P. discolor或蝙蝠作为研究物种的其他调查领域。

更新日期：2022-09-07

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