N⁶-methyladenosine (m⁶A) RNA modification is widely perceived as the most abundant and common modification in transcripts. This modification is dynamically regulated by specific m⁶A “writers”, “erasers” and “readers” and is reportedly involved in the occurrence and development of many diseases. Since m⁶A RNA modification was discovered in the 1970s, with the progress of relevant research technologies, an increasing number of functions of m⁶A have been reported, and a preliminary understanding of m⁶A has been obtained. In this review, we summarize the mechanisms through which m⁶A RNA modification is regulated from the perspectives of expression, posttranslational modification and protein interaction. In addition, we also summarize how external and internal environmental factors affect m⁶A RNA modification and its functions in tumors. The mechanisms through which m⁶A methylases, m⁶A demethylases and m⁶A-binding proteins are regulated are complicated and have not been fully elucidated. Therefore, we hope to promote further research in this field by summarizing these mechanisms and look forward to the future application of m⁶A in tumors.

N ⁶ -甲基腺苷 (m ⁶ A) RNA 修饰被广泛认为是转录本中最丰富和最常见的修饰。这种修饰受到特定的m ⁶ A“书写者”、“擦除者”和“阅读者”的动态调节，据报道参与了许多疾病的发生和发展。自20世纪70年代发现m ⁶ A RNA修饰以来，随着相关研究技术的进步，越来越多的m ⁶ A功能被报道，并对m ⁶ A有了初步的认识。在这篇综述中，我们从表达、翻译后修饰和蛋白质相互作用的角度总结了 m ^{6 A RNA 修饰的调控机制。}此外，我们还总结了外部和内部环境因素如何影响 m ⁶ A RNA 修饰及其在肿瘤中的功能。^{m 6} A 甲基化酶、m ⁶ A 去甲基化酶和 m ⁶ A 结合蛋白的调节机制很复杂，尚未完全阐明。因此，我们希望通过总结这些机制来推动该领域的进一步研究，并展望m ⁶ A在肿瘤中的未来应用。