One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice. This implied that accumulation of senescent cells promotes late-life diseases, particularly through action of senescent cell secretions (the senescence-associated secretory phenotype, or SASP). But what exactly is a senescent cell? Subsequent to the initial characterization of cellular senescence, it became clear that, prior to aging, this phenomenon is in fact adaptive. It supports tissue remodeling functions in a variety of contexts, including embryogenesis, parturition, and acute inflammatory processes that restore normal tissue architecture and function, such as wound healing, tissue repair after infection, and amphibian limb regeneration. In these contexts, such cells are normal and healthy and not in any way senescent in the true sense of the word, as originally meant by Hayflick. Thus, it is misleading to refer to them as “senescent.” Similarly, the common assertion that senescent cells accumulate with age due to stress and DNA damage is no longer safe, particularly given their role in inflammation—a process that becomes persistent in later life. We therefore suggest that it would be useful to update some terminology, to bring it into line with contemporary understanding, and to avoid future confusion. To open a discussion of this issue, we propose replacing the term cellular senescence with remodeling activation, and SASP with RASP (remodeling-associated secretory phenotype).

2010 年代生物老年学最引人注目的发现之一是证明消除衰老细胞可以延缓许多晚年疾病并延长小鼠的寿命。这意味着衰老细胞的积累会促进晚年疾病，特别是通过衰老细胞分泌物（衰老相关分泌表型，或 SASP）的作用。但衰老细胞到底是什么？在细胞衰老的初步表征之后，很明显，在衰老之前，这种现象实际上是适应性的。它支持各种情况下的组织重塑功能，包括胚胎发生、分娩和恢复正常组织结构和功能的急性炎症过程，例如伤口愈合、感染后组织修复和两栖动物肢体再生。在这些情况下，这些细胞是正常和健康的，不会像 Hayflick 最初所指的那样真正意义上的衰老。因此，将它们称为“衰老”是一种误导。同样，衰老细胞因压力和 DNA 损伤而随着年龄增长而积累的普遍说法不再安全，特别是考虑到它们在炎症中的作用——这一过程在以后的生活中变得持续存在。因此，我们建议更新一些术语，使其符合当代的理解，并避免未来的混淆。为了开启对这个问题的讨论，我们建议将术语替换为 衰老细胞因压力和 DNA 损伤而随着年龄增长而积累的普遍说法不再安全，特别是考虑到它们在炎症中的作用——这一过程在以后的生活中变得持续存在。因此，我们建议更新一些术语，使其符合当代的理解，并避免未来的混淆。为了开启对这个问题的讨论，我们建议将术语替换为 衰老细胞因压力和 DNA 损伤而随着年龄增长而积累的普遍说法不再安全，特别是考虑到它们在炎症中的作用——这一过程在以后的生活中变得持续存在。因此，我们建议更新一些术语，使其符合当代的理解，并避免未来的混淆。为了开启对这个问题的讨论，我们建议将术语替换为具有重塑激活的细胞衰老，以及具有RASP（重塑相关分泌表型）的SASP 。