Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases,Acta Neuropathologica

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Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases
Acta Neuropathologica ( IF 12.7 ) Pub Date : 2022-09-07 , DOI: 10.1007/s00401-022-02492-7
Philipp Sievers _{1,

2} , Martin Sill _{3,

4} , Daniel Schrimpf _{1,

2} , Dennis Friedel _{1,

2} , Dominik Sturm _{3,

5,

6} , Maria Gardberg _{7,

8} , Kathreena M Kurian ₉ , Lenka Krskova _{10,

11} , Ales Vicha _{10,

12} , Tina Schaller ₁₃ , Christian Hagel ₁₄ , Zied Abdullaev ₁₅ , Kenneth Aldape ₁₅ , Thomas S Jacques _{16,

17} , Andrey Korshunov _{1,

2,

3} , Wolfgang Wick _{18,

19} , Stefan M Pfister _{3,

4,

5} , Andreas von Deimling _{1,

2} , David T W Jones _{3,

6} , Felix Sahm _{1,

2,

3}

Affiliation

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pathology, Turku University Hospital, Turku, Finland.
Institute of Biomedicine, University of Turku, Turku, Finland.
Brain Tumour Research Centre, Bristol Medical School, University of Bristol, Bristol, UK.
Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.