This report describes two cases of late cartilage delamination in two young adults after two different autologous cell-based techniques for cartilage restoration: 1. Matrix-assisted autologous chondrocyte implantation (MACI) and 2. Hyaluronic acid-bone marrow aspirate concentrate (HA-BMAC). Both cases demonstrate that even in patients who do not present with any ongoing symptoms after primary surgery, a cellular-based graft’s subsequent delamination can occur later. It is possible that regardless of the technique used or the time passed since the surgery, a graft failure may occur at some level, causing delamination of a previously asymptomatic cartilage restoration graft and a traumatic event with long-term follow-up. Surgeons must be alert to this injury and describe histologic findings to determine where failure occurs.

中文翻译：

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基于细胞的修复程序后八年的关节软骨分层：病例报告

本报告描述了两名年轻成年人在两种不同的基于自体细胞的软骨修复技术后发生的两例晚期软骨脱层：1. 基质辅助自体软骨细胞植入 (MACI) 和 2. 透明质酸-骨髓抽吸浓缩物 (HA-BMAC) ）。这两个案例都表明，即使在初次手术后没有出现任何持续症状的患者中，基于细胞的移植物随后也可能发生分层。无论使用何种技术或手术后经过的时间如何，移植失败都可能在一定程度上发生，导致先前无症状的软骨修复移植物分层和长期随访的创伤事件。外科医生必须警惕这种损伤并描述组织学发现以确定失败发生的位置。