Brain injury in out-of-hospital cardiac arrest (OHCA) survivors affects health status and health-related quality of life (HRQoL). It is unknown how HRQoL evolves over time, and assessments at different time points may lead to different results. In a NORCAST sub study, OHCA survivors eligible for health status (EQ-5D-3L) and HRQoL (SF-36) assessments were examinated six months and five years after OHCA. At five-year follow-up, survivors also retrospectively assessed their health status for each consecutive year following OHCA. The next of kin independently assessed health status and HRQoL of their respective OHCA survivors. Among 138 survivors alive after six months and 117 after five years, 80 (88% male) completed both follow-ups. Health status and HRQoL remained stable over time, except for increasing SF-36 mental summary score and decreasing physical functioning and physical component score. Anxiety and depression levels were generally low, although younger survivors stated more anxiety than older survivors. Retrospective assessment showed reduced health status for the first two years, which increased only from the third year. Explorative analyses revealed that younger age, longer time to return of spontaneous circulation (tROSC) and late awakening affected health status, particularly in the first two years post-arrest. OHCA survivors showed stable health status and HRQoL with only minor differences between six months and five years. Younger survivors with long tROSC, late awakening, and more anxiety and depression symptoms at six months, had reduced health status the first two years with significant improvements towards the fourth year.

中文翻译：

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院外心脏骤停幸存者六个月至五年内健康状况和健康相关生活质量的变化——一项 NORCAST 子研究


院外心脏骤停 (OHCA) 幸存者的脑损伤会影响健康状况和健康相关的生活质量 (HRQoL)。 HRQoL 如何随时间演变尚不清楚，不同时间点的评估可能会导致不同的结果。在 NORCAST 子研究中，对符合健康状况 (EQ-5D-3L) 和 HRQoL (SF-36) 评估资格的 OHCA 幸存者在 OHCA 后六个月和五年进行了检查。在五年随访中，幸存者还回顾性评估了 OHCA 后连续每年的健康状况。近亲独立评估了各自 OHCA 幸存者的健康状况和 HRQoL。六个月后存活的 138 名幸存者和五年后存活的 117 名幸存者中，有 80 人（88% 为男性）完成了两次随访。随着时间的推移，健康状况和 HRQoL 保持稳定，除了 SF-36 心理总结分数增加以及身体功能和身体成分分数下降之外。尽管年轻的幸存者比年长的幸存者表现出更多的焦虑，但焦虑和抑郁水平普遍较低。回顾性评估显示，前两年健康状况有所下降，从第三年开始才有所上升。探索性分析显示，年龄较小、恢复自主循环（tROSC）时间较长和晚醒会影响健康状况，特别是在被捕后的头两年。 OHCA 幸存者表现出稳定的健康状况和 HRQoL，六个月和五年之间只有微小差异。那些 tROSC 较长、觉醒较晚、六个月时出现更多焦虑和抑郁症状的年轻幸存者，在前两年健康状况有所下降，但到第四年有显着改善。