Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity,Angewandte Chemie International Edition

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Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-06 , DOI: 10.1002/anie.202211054
Heng Li ₁ , Jeroen S Dickschat ₁

Affiliation

Two analogues of geranylgeranyl diphosphate with shifted double bond were enzymatically converted with twelve diterpene synthases. The double bond shift causes a change of reactivity that results in the formation of many diterpenes with novel skeletons. A total number of 28 new diterpenes is reported and their mechanism of formation is discussed.

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