Two Radical SAM Enzymes Are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin,Angewandte Chemie International Edition

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Two Radical SAM Enzymes Are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-05 , DOI: 10.1002/anie.202210362
Po-Hsun Fan ₁ , Yujie Geng ₂ , Anthony J Romo ₂ , Aoshu Zhong ₂ , Jiawei Zhang ₁ , Yu-Cheng Yeh ₁ , Yu-Hsuan Lee ₁ , Hung-Wen Liu _{1,

2}

Affiliation

The biosynthesis of the oxetane nucleoside albucidin was demonstrated in vitro to proceed in two steps involving the cobalamin dependent radical S-adenosyl-l-methionine (SAM) enzyme AlsB, which catalyzes a ring contraction reaction, and the radical SAM enzyme AlsA, which is responsible for the elimination of a one-carbon fragment. These activities are uncommon among the presently described radical SAM enzymes.

中文翻译：

两种自由基 SAM 酶对于体外生产氧杂环丁烷核苷抗病毒剂阿布西丁是必要且充分的

氧杂环丁烷核苷白布西丁的生物合成在体外被证明分两步进行，涉及钴胺素依赖性自由基 S-腺苷-L-甲硫氨酸(SAM) 酶 AlsB（催化环收缩反应）和自由基 SAM 酶 AlsA（催化环收缩反应）。负责消除一碳碎片。这些活性在目前描述的自由基 SAM 酶中并不常见。

更新日期：2022-09-05

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