After patent foramen ovale interventional closure, puncture of the interatrial septum through the occluder is difficult but sometimes needed for further interventional treatment. This paper presents findings from an in vivo experimental study of a reserved atrial septal puncture area patent foramen ovale occluder.

A patent foramen ovale model was established in canines using trans-septal puncture of the fossa ovale and high-pressure balloon dilation. Then, patent foramen ovale closure was performed with a reserved atrial septal puncture area and all canines were raised for 3 months. Then, the occluder was crossed and left atrial angiography was performed on the septal area with the occluder. Finally, DSA angiography, echocardiography, and histology were used to evaluate the performance and feasibility of the reserved atrial septal puncture area.

A patent foramen ovale model was successfully established in 10 canines using the atrial septal puncture method. The average diameter of the patent foramen ovale was 3.77 ±0.19 mm, and the patent foramen ovale was successfully closed in all canines using a reserved atrial septal puncture area. As assessed using transoesophageal echocardiography, the new occluder exhibited an ideal position and was occluded entirely without a residual shunt intraoperatively and postoperatively. A 100% success rate of atrial septum puncture was achieved across the new occluder. The occluders were completely endothelialised 3 months post-implantation.

The reserved atrial septal puncture area was effective in patent foramen ovale closure and exhibited positive sealing performance and biological compatibility. Trans-septal puncture was feasible and effective after reserved atrial septal puncture area patent foramen ovale closure.

卵圆孔未闭介入封堵后，通过封堵器穿刺房间隔比较困难，但有时需要进一步介入治疗。本文介绍了保留房间隔穿刺区域卵圆孔未闭封堵器的体内实验研究结果。

采用经房间隔穿刺卵圆窝和高压球囊扩张的方法在犬科动物中建立卵圆孔未闭模型。然后，保留房间隔穿刺区域，进行卵圆孔未闭封堵术，并将所有尖牙抬起3个月。然后交叉封堵器，用封堵器对房间隔区域进行左心房造影。最后通过DSA血管造影、超声心动图和组织学评估保留房间隔穿刺区域的性能和可行性。

采用房间隔穿刺法成功建立10只犬卵圆孔未闭模型。卵圆孔未闭的平均直径为3.77±0.19 mm，使用保留的房间隔穿刺区域成功闭合所有犬齿的卵圆孔未闭。根据经食管超声心动图的评估，新的封堵器表现出理想的位置，并且在术中和术后完全封堵，没有残留分流。新型封堵器的房间隔穿刺成功率达到 100%。植入后 3 个月，封堵器完全内皮化。

保留的房间隔穿刺区域可有效封闭卵圆孔未闭，并表现出良好的密封性能和生物相容性。保留房间隔穿刺区域卵圆孔未闭封堵后，房间隔穿刺可行、有效。