Thermogenic brown and beige adipocytes have gained much attention as potential therapeutic targets in obesity and related cardiometabolic disease. A recent paper in Nature identifies inosine, released from apoptotic brown adipocytes, as an inducer of thermogenic adipose tissue, thereby uncovering an unexpected and novel mechanism of adipose tissue plasticity.

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AcroBATics：死亡的棕色脂肪细胞如何引发褐变

产热棕色和米色脂肪细胞作为肥胖和相关心脏代谢疾病的潜在治疗靶点而备受关注。Nature 最近的一篇论文将凋亡的棕色脂肪细胞释放的肌苷确定为产热脂肪组织的诱导剂，从而揭示了一种意想不到的脂肪组织可塑性的新机制。