Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma,Hepatology

当前位置： X-MOL 学术 › Hepatology › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma
Hepatology ( IF 12.9 ) Pub Date : 2022-09-04 , DOI: 10.1002/hep.32775
Hongting Huang ₁ , Liang Wu _{2,

3} , Li Lu _{2,

4} , Zijie Zhang ₁ , Bijun Qiu ₁ , Jialin Mo ₂ , Yi Luo ₁ , Zhifeng Xi ₁ , Mingxuan Feng ₁ , Ping Wan ₁ , Jianjun Zhu ₁ , Dingye Yu ₅ , Wei Wu ₄ , Kezhe Tan ₄ , Jiangbin Liu ₄ , Qingfeng Sheng ₄ , Ting Xu ₄ , Jinyan Huang _{6,

7,

8} , Zhibao Lv ₄ , Yujie Tang _{2,

9} , Qiang Xia _{1,

10,

11}

Affiliation

Department of Liver Surgery, Renji Hospital, School of Medicine , Shanghai Jiaotong University , Shanghai , China.
Research Center of Translational Medicine, Shanghai Children's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology , Shanghai Jiaotong University School of Medicine , Shanghai , China.
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, School of Medicine , Shanghai Jiaotong University , Shanghai , China.
Department of General Surgery, Shanghai Children's Hospital , Shanghai Jiaotong University , Shanghai , China.
Department of Gastrointestinal Surgery , Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
Biomedical Big Data Center , The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou , China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease , Zhejiang University School of Medicine First Affiliated Hospital , Hangzhou , China.
Zhejiang University Cancer Center , Zhejiang University , Hangzhou , China.
Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology , Shanghai Jiaotong University School of Medicine , Shanghai , China.
Shanghai Engineering Research Centre of Transplantation and Immunology , Shanghai , China.
Shanghai Institute of Transplantation , Shanghai , China.

Hepatoblastoma (HB) is the predominant type of childhood liver cancer. Treatment options for the clinically advanced HB remain limited. We aimed to dissect the cellular and molecular basis underlying HB oncogenesis and heterogeneity at the single-cell level, which could facilitate a better understanding of HB at both the biological and clinical levels.

中文翻译：