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Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma
Hepatology ( IF 12.9 ) Pub Date : 2022-09-04 , DOI: 10.1002/hep.32775
Hongting Huang 1 , Liang Wu 2, 3 , Li Lu 2, 4 , Zijie Zhang 1 , Bijun Qiu 1 , Jialin Mo 2 , Yi Luo 1 , Zhifeng Xi 1 , Mingxuan Feng 1 , Ping Wan 1 , Jianjun Zhu 1 , Dingye Yu 5 , Wei Wu 4 , Kezhe Tan 4 , Jiangbin Liu 4 , Qingfeng Sheng 4 , Ting Xu 4 , Jinyan Huang 6, 7, 8 , Zhibao Lv 4 , Yujie Tang 2, 9 , Qiang Xia 1, 10, 11
Affiliation  

Hepatoblastoma (HB) is the predominant type of childhood liver cancer. Treatment options for the clinically advanced HB remain limited. We aimed to dissect the cellular and molecular basis underlying HB oncogenesis and heterogeneity at the single-cell level, which could facilitate a better understanding of HB at both the biological and clinical levels.

中文翻译:


单细胞转录组学揭示肝母细胞瘤的细胞结构和发育轨迹



肝母细胞瘤(HB)是儿童肝癌的主要类型。临床晚期 HB 的治疗选择仍然有限。我们的目的是在单细胞水平上剖析 HB 肿瘤发生和异质性的细胞和分子基础,这有助于在生物学和临床水平上更好地了解 HB。
更新日期:2022-09-04
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