Water T2 could predict functional decline in patients with dysferlinopathy,Journal of Cachexia, Sarcopenia and Muscle

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Water T2 could predict functional decline in patients with dysferlinopathy
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2022-09-04 , DOI: 10.1002/jcsm.13063
Ursula Moore ₁ , Ericky Caldas de Almeida Araújo _{2,

3} , Harmen Reyngoudt _{2,

3} , Heather Gordish-Dressman _{4,

5} , Fiona E Smith ₆ , Ian Wilson ₆ , Meredith James ₁ , Anna Mayhew ₁ , Laura Rufibach ₇ , John W Day ₈ , Kristi J Jones ₉ , Diana X Bharucha-Goebel _{10,

11} , Emmanuelle Salort-Campana ₁₂ , Alan Pestronk ₁₃ , Maggie C Walter ₁₄ , Carmen Paradas ₁₅ , Tanya Stojkovic ₁₆ , Madoka Mori-Yoshimura ₁₇ , Elena Bravver ₁₈ , Elena Pegoraro ₁₉ , Jerry R Mendell ₂₀ , , Kate Bushby ₁ , Andrew M Blamire ₆ , Volker Straub ₁ , Pierre G Carlier ₂₁ , Jordi Diaz-Manera _{1,

22,

23}

Affiliation

The John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France.
NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France.
Center for Translational Science, Division of Biostatistics and Study Methodology, Children's National Health System, Washington, DC, USA.
Pediatrics, Epidemiology and Biostatistics, George Washington University, Washington, DC, USA.
Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Jain Foundation, Seattle, WA, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW, Australia.
Department of Neurology, Children's National Health System, Washington, DC, USA.
National Institutes of Health (NINDS), Bethesda, MD, USA.
Service des maladies neuromusculaire et de la SLA, Hôpital de La Timone, Marseille, France.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.
Neuromuscular Unit, Department of Neurology, Hospital U. Virgen del Rocío/Instituto de Biomedicina de Sevilla, Sevilla, Spain.
Centre de référence des maladies neuromusculaires, Institut de Myologie, AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.
Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Neuroscience Institute, Carolinas Neuromuscular/ALS-MDA Center, Carolinas HealthCare System, Charlotte, NC, USA.
Department of Neuroscience, University of Padova, Padua, Italy.
The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Université Paris-Saclay, CEA, DRF, Service Hospitalier Frederic Joliot, Orsay, France.
Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain.

Water T2 (T2_H2O) mapping is increasingly being used in muscular dystrophies to assess active muscle damage. It has been suggested as a surrogate outcome measure for clinical trials. Here, we investigated the prognostic utility of T2_H2O to identify changes in muscle function over time in limb girdle muscular dystrophies.

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