Background

Tourette syndrome (TS) is a disorder characterized by a history of multiple motor tics and the emergence of at least one vocal tic during a period of the disorder. The current investigation sought to clarify the prevalence statistics for TS using a systematic review and meta-analysis.

Methods

This systematic review and meta-analysis covered the period between 1986 and 2022. Embase, Scopus, PubMed, Web of Science, and Google Scholar were searched to locate articles pertinent to the study topic. The I² index was used to examine the heterogeneity of the studies, and a comprehensive meta-analysis was employed to analyze the data.

Results

Ultimately, 30 studies (39 outcomes) were included in the meta-analysis and systematic review. The results showed the global prevalence of TS to be 0.5% (95% confidence interval [CI], 0.3% to 0.8%), with the highest rate of spread observed in the Americas at 0.6% (95% CI, 0.2% to 1.6 %). Analyzing the subgroups of the sample revealed that the highest prevalence was associated with the population of children and adolescents at 0.7% (95% CI, 0.4% to 1.4%) and males at 0.5% (95% CI, 0.2% to 1.0%).

Conclusions

This comprehensive review and meta-analysis revealed that the prevalence of TS worldwide is sufficiently high, such that attention of medical specialists and health policy makers is warranted.

中文翻译：

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图雷特综合征患病率的系统回顾和荟萃分析；1986 年至 2022 年

背景

图雷特综合征 (TS) 是一种疾病，其特征是有多次运动抽动病史，并且在疾病发作期间出现至少一次发声抽动。目前的调查试图使用系统回顾和荟萃分析来阐明 TS 的流行统计数据。

方法

该系统回顾和元分析涵盖了 1986 年至 2022 年期间。搜索了 Embase、Scopus、PubMed、Web of Science 和 Google Scholar 以查找与研究主题相关的文章。I ²指数用于检查研究的异质性，并采用全面的荟萃分析来分析数据。

结果

最终，30 项研究（39 项结果）被纳入荟萃分析和系统评价。结果显示 TS 的全球患病率为 0.5%（95% 置信区间 [CI]，0.3% 至 0.8%），在美洲观察到的传播率最高，为 0.6%（95% CI，0.2% 至 1.6 %)。分析样本的亚组显示，最高患病率与儿童和青少年人口相关，为 0.7%（95% CI，0.4% 至 1.4%），男性为 0.5%（95% CI，0.2% 至 1.0%） .

结论

这项综合审查和荟萃分析表明，全球 TS 的患病率非常高，因此需要引起医学专家和卫生政策制定者的关注。