Prosthetic reconstructive procedures have become the mainstay in contemporary surgical treatment following resection of extremity bone neoplasms. Given that these patients are of young age most of the time, achievement of robust functional outcomes is of paramount importance. The aim of this study is to assess the impact of this procedure on the gait parameters of cancer patients compared to healthy individuals. The Medline, Scopus and Cochrane databases were systematically searched until January 2022 for eligible studies. Gait parameters measured by gait analysis after prosthetic reconstruction were the outcomes of interest. Eight cohort studies were included in our analysis. From these, seven studied prosthetic reconstruction of the knee (distal femur or proximal tibia) and only one exclusively studied prostetic reconstructions of the proximal femur. Compared to healthy individuals a significant decrease was evident in gait velocity (-0.16 m/sec, 95 %CI: −0.23 to −0.09, p-value < 0.001), in stride length (-6.07 %height, 95 %CI: −9,36 to −2.78, p-value < 0.001), in cadence (-3.96 stride/min, 95 %CI: −5.41 to −2.51, p-value < 0.001) and significant increase in cycle time (0.10 s, 95 %CI: 0.03 to 0.17, p-value = 0.005). Prosthetic reconstruction following lower limb tumor resection significantly affects the gait of patients. This knowledge can be utilized for further refinement of surgical techniques, rehabilitation strategies and follow-up programming.

在切除四肢骨肿瘤后，假体重建手术已成为当代手术治疗的支柱。鉴于这些患者大部分时间都很年轻，因此实现稳健的功能结果至关重要。本研究的目的是评估与健康个体相比，该程序对癌症患者步态参数的影响。系统搜索 Medline、Scopus 和 Cochrane 数据库直至 2022 年 1 月，以寻找符合条件的研究。假体重建后通过步态分析测量的步态参数是感兴趣的结果。我们的分析包括八项队列研究。从这些，七个研究了膝关节（股骨远端或胫骨近端）的假体重建，只有一个专门研究了股骨近端的假体重建。与健康人相比，步态速度明显下降（-0.16 m/sec , 95 %CI: -0.23 to -0.09, p-value < 0.001), in stride length (-6.07 % height, 95 %CI: -9,36 to -2.78, p-value < 0.001), in cadence ( -3.96 步幅/分钟，95 %CI：-5.41 至 -2.51，p 值 < 0.001）和循环时间显着增加（0.10 秒，95 %CI：0.03 至 0.17，p 值 = 0.005）。下肢肿瘤切除后的假体重建显着影响患者的步态。这些知识可用于进一步完善手术技术、康复策略和后续计划。