Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-accelerated mouse prone 10 model,Journal of Cachexia, Sarcopenia and Muscle

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Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-accelerated mouse prone 10 model
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2022-09-04 , DOI: 10.1002/jcsm.13058
Aiko Inoue _{1,

2} , Limei Piao ₃ , Xueling Yue ₃ , Zhe Huang ₄ , Lina Hu ₅ , Hongxian Wu ₆ , Xiangkun Meng ₂ , Wenhu Xu ₃ , Chenglin Yu ₃ , Takeshi Sasaki ₇ , Kohji Itakura ₈ , Hiroyuki Umegaki _{1,

2} , Masafumi Kuzuya _{1,

2} , Xian Wu Cheng ₃

Affiliation

Young bone marrow transplantation (YBMT) has been shown to stimulate vascular regeneration in pathological conditions, including ageing. Here, we investigated the benefits and mechanisms of the preventive effects of YBMT on loss of muscle mass and function in a senescence-associated mouse prone 10 (SAMP10) model, with a special focus on the role of growth differentiation factor 11 (GDF-11).

中文翻译：

年轻骨髓移植可预防衰老加速小鼠易感 10 模型中与衰老相关的肌肉萎缩

年轻骨髓移植 (YBMT) 已被证明可以在包括衰老在内的病理条件下刺激血管再生。在这里，我们研究了 YBMT 对衰老相关小鼠易感 10 (SAMP10) 模型中肌肉质量和功能损失的预防作用的益处和机制，特别关注生长分化因子 11 (GDF-11) 的作用).

更新日期：2022-09-04

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