Identification of novel neutralizing determinants for protection against HCV,Hepatology

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Identification of novel neutralizing determinants for protection against HCV
Hepatology ( IF 12.9 ) Pub Date : 2022-09-03 , DOI: 10.1002/hep.32772
Garazi P Alzua _{1,

2} , Anne F Pihl _{1,

2} , Anna Offersgaard _{1,

2} , Rodrigo Velázquez-Moctezuma _{1,

2} , Carlos R Duarte Hernandez _{1,

2} , Elias H Augestad _{1,

2} , Ulrik Fahnøe _{1,

2} , Christian K Mathiesen _{1,

2} , Henrik Krarup _{3,

4} , Mansun Law ₅ , Jannick Prentoe _{1,

2} , Jens Bukh _{1,

2} , Judith M Gottwein _{1,

2}

Affiliation

HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine. N-linked glycosylation of viral envelope proteins is a key mechanism for such evasion. To facilitate rational vaccine design, we aimed to identify determinants of protection of conserved neutralizing epitopes.

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