A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation,Hepatology

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A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation
Hepatology ( IF 12.9 ) Pub Date : 2022-09-03 , DOI: 10.1002/hep.32773
Mikal Jacob Hole _{1,

2,

3} , Kristin Kaasen Jørgensen _{1,

4} , Kristian Holm _{1,

2,

3} , Peder R Braadland _{1,

2,

3} , Malin Holm Meyer-Myklestad _{2,

5,

6} , Asle Wilhelm Medhus ₇ , Dag Henrik Reikvam _{2,

5} , Alexandra Götz _{1,

2,

3} , Krzysztof Grzyb ₈ , Kirsten Muri Boberg _{1,

2,

9} , Tom Hemming Karlsen _{1,

2,

3,

9} , Martin Kummen _{1,

2,

10} , Johannes R Hov _{1,

2,

3,

9}

Affiliation

Norwegian PSC Research Centre , Department of Transplantation Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.
Institute of Clinical Medicine , University of Oslo , Oslo , Norway.
Research Institute of Internal Medicine , Oslo University Hospital , Rikshospitalet , Oslo , Norway.
Department of Gastroenterology , Akershus University Hospital , Lørenskog , Norway.
Department of Infectious Diseases , Oslo University Hospital, Ullevål , Oslo , Norway.
Department of Microbiology , Oslo University Hospital, Ullevål , Oslo , Norway.
Department of Gastroenterology , Oslo University Hospital, Ullevål , Oslo , Norway.
Division of Pathology , Oslo University Hospital, Rikshospitalet , Oslo , Norway.
Section of Gastroenterology , Department of Transplantation Medicine , Oslo University Hospital, Rikshospitalet , Oslo , Norway.
Department of Oncology , Oslo University Hospital , Oslo , Norway.

Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal microbiota are less consistent. We aimed to use a large colonoscopy cohort to investigate key knowledge gaps, including the role of gut microbiota in PSC with inflammatory bowel disease (IBD), the effect of liver transplantation (LT), and whether recurrent PSC (rPSC) may be used to define consistent microbiota features in PSC irrespective of LT.

中文翻译：

原发性硬化性胆管炎肝移植前后共有的粘膜肠道微生物群特征

原发性硬化性胆管炎（PSC）中粪便微生物群的几个特征已被描述，而粘膜微生物群的数据则不太一致。我们的目的是利用大型结肠镜检查队列来调查关键知识差距，包括肠道微生物群在炎症性肠病 (IBD) PSC 中的作用、肝移植 (LT) 的影响，以及复发性 PSC (rPSC) 是否可用于治疗定义 PSC 中一致的微生物群特征，与 LT 无关。

更新日期：2022-09-03

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