Summary:In this issue of Cancer Discovery, Patel and colleagues explore the synergistic lethality of PRC2 inactivation and DNMT inhibition in malignant peripheral nerve sheath tumor cells. Reactivation of retrotransposons under this dual control suggests that the viral mimicry response contributes to enhanced cytotoxicity with potential clinical implications.See related article by Patel et al., p. 2120 (5).

中文翻译：

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PRC2 缺失和 DNMT 抑制促进癌症中的病毒模仿

摘要：在本期《Cancer Discovery》中，Patel 及其同事探讨了 PRC2 失活和 DNMT 抑制对恶性周围神经鞘肿瘤细胞的协同致死作用。在这种双重控制下逆转录转座子的重新激活表明，病毒拟态反应有助于增强细胞毒性，具有潜在的临床意义。参见 Patel 等人的相关文章，第 17 页。2120（5）。