Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response,ChemMedChem

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Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response
ChemMedChem ( IF 3.6 ) Pub Date : 2022-09-02 , DOI: 10.1002/cmdc.202200415
Diana Ainembabazi ₁ , Xinran Geng ₂ , Navnath S Gavande _{3,

4} , John J Turchi ₁ , Youwei Zhang ₂

Affiliation

Anticancer compounds with heart: This manuscript reports the synthesis of derivatives of Antiaris toxicaria 2 (cardiac glycosides). Biological evaluation of these analogues in the signalling of the DNA damage response indicate that their activity can be enhanced by tuning key structural moieties.

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