Factors related to ultrafiltration volume with icodextrin dialysate use in children,Pediatric Nephrology

当前位置： X-MOL 学术 › Pediatr. Nephrol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Factors related to ultrafiltration volume with icodextrin dialysate use in children
Pediatric Nephrology ( IF 2.6 ) Pub Date : 2022-09-02 , DOI: 10.1007/s00467-022-05720-0
Naoaki Mikami ₁ , Riku Hamada _{1,

2} , Ryoko Harada ₁ , Yuko Hamasaki _{1,

3} , Kenji Ishikura _{1,

4} , Masataka Honda _{1,

2} , Hiroshi Hataya _{1,

2,

5}

Affiliation

Background

Icodextrin has a lower absorption rate, and icodextrin peritoneal dialysate contributes to more water removal than glucose dialysate in patients with high peritoneal permeability. There are limited data on icodextrin dialysate use in children.

Methods

This study included all pediatric patients who received peritoneal equilibration tests and peritoneal dialysis with icodextrin dialysate at the study center. The factors related to ultrafiltration volume with icodextrin dialysate with long dwell time were statistically analyzed. Then the ultrafiltration volume with icodextrin and medium-concentration glucose dialysate was compared in individual cycles in the same patients.

Results

Thirty-six samples were included in the icodextrin group, and nine samples were used to compare the ultrafiltration volume with icodextrin and glucose dialysate. Dwell time, D/P-creatinine, D/D₀-glucose, age, height, and weight correlated significantly with the ultrafiltration volume of icodextrin dialysate (p < 0.05). A dwell volume equal to or more than 550 mL/m² was associated with a significantly higher ultrafiltration volume than a lower dwell volume (p = 0.039). Multiple regression analysis revealed that dwell time (p = 0.038) and height (p < 0.01) correlated with ultrafiltration volume significantly. In addition, the ultrafiltration volume was superior (p < 0.01), and dwell time was longer (p = 0.02), with icodextrin dialysate than with medium-concentration glucose dialysate.

Conclusions

The ultrafiltration volume with icodextrin dialysate decreases in patients with small stature. Providing sufficient dwell time and volume is important for maximal water removal even in children. Ultrafiltration volume is superior with icodextrin than medium-concentration glucose dialysate for long dwell times.

Graphical abstract

中文翻译：

儿童使用艾考糊精透析液超滤量的相关因素

背景

艾考糊精的吸收率较低，艾考糊精腹膜透析液在高腹膜通透性患者中比葡萄糖透析液有助于更多的水分清除。关于儿童使用艾考糊精透析液的数据有限。

方法

该研究包括所有在研究中心接受腹膜平衡试验和使用艾考糊精透析液进行腹膜透析的儿科患者。统计分析长停留时间艾考糊精透析液超滤量的相关因素。然后在同一患者的各个周期中比较艾考糊精和中等浓度葡萄糖透析液的超滤量。

结果

艾考糊精组包括 36 个样品，其中 9 个样品用于比较超滤体积与艾考糊精和葡萄糖透析液。停留时间、D/P-肌酐、D/D ₀ -葡萄糖、年龄、身高和体重与艾考糊精透析液的超滤量显着相关（p < 0.05）。与较低的驻留体积相比，等于或大于 550 mL/m ²的驻留体积与显着更高的超滤体积相关 ( p = 0.039)。多元回归分析显示停留时间 ( p = 0.038) 和高度 ( p < 0.01) 与超滤量显着相关。此外，超滤体积更优（p < 0.01)，并且停留时间更长 ( p = 0.02)，与中等浓度葡萄糖透析液相比，艾考糊精透析液。