Recent advances in small-molecule fluorescent probes for studying ferroptosis,Chemical Society Reviews

当前位置： X-MOL 学术 › Chem. Soc. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent advances in small-molecule fluorescent probes for studying ferroptosis
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-09-02 , DOI: 10.1039/d1cs01167g
Ya-Lin Qi _{1,

2,

3,

4} , Hai-Rong Wang ₃ , Li-Li Chen ₃ , Yong-Tao Duan _{1,

2} , Sheng-Yu Yang ₄ , Hai-Liang Zhu _{1,

2,

3}

Affiliation

Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death driven by excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality of cell death is involved in the development and progression of several diseases including cancer, cardiovascular diseases (CVDs), neurodegenerative disorders, etc. However, the pathogenesis and signalling pathways of ferroptosis are not fully understood, possibly due to the lack of robust tools for the highly selective and sensitive imaging of ferroptosis analytes in complex living systems. Up to now, various small-molecule fluorescent probes have been applied as promising chemosensors for studying ferroptosis through tracking the biomolecules or microenvironment-related parameters in vitro and in vivo. In this review, we comprehensively reviewed the recent development of small-molecule fluorescent probes for studying ferroptosis, with a focus on the analytes, design strategies and bioimaging applications. We also provided new insights to overcome the major challenges in this emerging field.

中文翻译：

研究铁死亡的小分子荧光探针的最新进展

铁死亡是一种由过度脂质过氧化 (LPO) 驱动的铁依赖性、非凋亡形式的程序性细胞死亡。越来越多的证据表明，细胞死亡的独特方式涉及多种疾病的发展和进展，包括癌症、心血管疾病 (CVD)、神经退行性疾病等。然而，铁死亡的发病机制和信号通路尚不完全清楚，可能是由于由于缺乏强大的工具来对复杂生命系统中的铁死亡分析物进行高选择性和灵敏的成像。到目前为止，各种小分子荧光探针已被用作通过体外追踪生物分子或微环境相关参数来研究铁死亡的有前景的化学传感器。在体内。在这篇综述中，我们全面回顾了用于研究铁死亡的小分子荧光探针的最新发展，重点关注分析物、设计策略和生物成像应用。我们还提供了新的见解，以克服这一新兴领域的主要挑战。

更新日期：2022-09-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11