Aprotic ether solvents, such as tetrahydrofuran, diethyl ether, cyclopentyl methyl ether, 2-methyltetrahydrofuran, dioxane, etc., are widely used in the field of organic synthesis due to their good solvent properties and utility for organometallic reactions. However, most of the traditional polar aprotic solvents from petroleum have disadvantages such as toxicity and environmental unfriendliness. Consequently, 2-methyltetrahydrofuran, a green solvent derived from the hemicellulose component of biomass, has recently been of great interest due to its excellent performance synthesis. In this paper, 2,5-dimethyltetrahydrofuran, derived from the cellulose component of biomass, has been studied in detail as a potential greener solvent due to its higher boiling point, lower water solubility, and better stability as compared to 2-methyltetrahydrofuran or tetrahydrofuran. These results showed that 2,5-dimethyltetrahydrofuran offers excellent performance in the fields of organometallic reactions, biphasic reactions, and extraction.

中文翻译：

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生物基 2,5-二甲基四氢呋喃作为绿色非质子醚溶剂

质子惰性醚类溶剂，如四氢呋喃、乙醚、环戊基甲基醚、2-甲基四氢呋喃、二恶烷等，因其良好的溶剂性能和对有机金属反应的实用性而被广泛应用于有机合成领域。然而，大多数来自石油的传统极性非质子溶剂具有毒性和环境不友好等缺点。因此，2-甲基四氢呋喃是一种源自生物质半纤维素成分的绿色溶剂，由于其优异的合成性能，最近引起了人们的极大兴趣。在本文中，源自生物质的纤维素成分的 2,5-二甲基四氢呋喃因其沸点高、水溶性低、与2-甲基四氢呋喃或四氢呋喃相比具有更好的稳定性。这些结果表明，2,5-二甲基四氢呋喃在有机金属反应、双相反应和萃取领域具有优异的性能。