The diagnosis of periprosthetic joint infection (PJI) continues to present a significant clinical challenge. New biomarkers have been proposed to support clinical decision-making; among them, synovial fluid alpha-defensin has gained interest. Current research methodology suggests reference methods are needed to establish solid evidence for use of the test. This prospective study aims to evaluate the diagnostic accuracy of high-performance liquid chromatography coupled with the mass spectrometry (LC-MS) method to detect alpha-defensin in synovial fluid.

中文翻译：

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膝关节假体周围感染检查中的滑液α-防御素：液相色谱-质谱法检测滑液中的α-防御素。

假体周围感染（PJI）的诊断仍然是一个重大的临床挑战。已经提出了新的生物标志物来支持临床决策；其中，滑液α-防御素引起了人们的兴趣。当前的研究方法表明，需要参考方法来建立使用该测试的可靠证据。这项前瞻性研究旨在评估高效液相色谱结合质谱 (LC-MS) 方法检测滑液中 α-防御素的诊断准确性。