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Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes
ChemMedChem ( IF 3.6 ) Pub Date : 2022-08-31 , DOI: 10.1002/cmdc.202200328 Paolo Coghi 1 , Ivan A Yaremenko 2 , Parichat Prommana 3 , Jia Ning Wu 4 , Rui Long Zhang 4 , Jerome P L Ng 4 , Yulia Yu Belyakova 2 , Betty Yuen Kwan Law 4 , Peter S Radulov 2 , Chairat Uthaipibull 3, 5 , Vincent Kam Wai Wong 4 , Alexander O Terent'ev 2
ChemMedChem ( IF 3.6 ) Pub Date : 2022-08-31 , DOI: 10.1002/cmdc.202200328 Paolo Coghi 1 , Ivan A Yaremenko 2 , Parichat Prommana 3 , Jia Ning Wu 4 , Rui Long Zhang 4 , Jerome P L Ng 4 , Yulia Yu Belyakova 2 , Betty Yuen Kwan Law 4 , Peter S Radulov 2 , Chairat Uthaipibull 3, 5 , Vincent Kam Wai Wong 4 , Alexander O Terent'ev 2
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Bridged aminoperoxides exhibit good activity and selectivity toward the A549 lung cancer cell line. Bridged ozonides demonstrate high antimalarial activity in vitro and selectivity against the chloroquine-resistant P. falciparum strain K1. Ozonides induce apoptosis in HepG2 cells through a reactive oxygen species (ROS)-independent dysfunction pathway.
中文翻译：
桥接臭氧化物、氨基过氧化物和四恶烷的抗疟和抗癌活性评价
桥接氨基过氧化物对 A549 肺癌细胞系表现出良好的活性和选择性。桥联臭氧化物在体外表现出高抗疟活性，并且对耐氯喹的恶性疟原虫菌株 K1 具有选择性。Ozonides 通过活性氧 (ROS) 非依赖性功能障碍途径诱导 HepG2 细胞凋亡。
更新日期：2022-08-31
中文翻译：
桥接臭氧化物、氨基过氧化物和四恶烷的抗疟和抗癌活性评价
桥接氨基过氧化物对 A549 肺癌细胞系表现出良好的活性和选择性。桥联臭氧化物在体外表现出高抗疟活性，并且对耐氯喹的恶性疟原虫菌株 K1 具有选择性。Ozonides 通过活性氧 (ROS) 非依赖性功能障碍途径诱导 HepG2 细胞凋亡。
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